Results 31 to 40 of about 23,384 (208)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Extensive microbial and functional diversity within the chicken cecal microbiome [PDF]

, 2014
Chickens are major source of food and protein worldwide. Feed conversion and the health of chickens relies on the largely unexplored complex microbial community that inhabits the chicken gut, including the ceca.
Sergeant Martin J., Cogan, Tristan A, Penn, Charles W, Michael R Bedford, Pallen, Mark J., Bedford Michael R., Charles W Penn, Mark J. Pallen, Chrystala Constantinidou (161352), Bedford, Michael R, Bedford, Michael R., Charles W. Penn (161371), Constantinidou Chrystala, Mark J Pallen, Charles W. Penn, Tristan A Cogan, Martin J. Sergeant (161344), Constantinidou, Chrystala, Michael R. Bedford, Sergeant, Martin J, Penn Charles W., Pallen, Mark J, Martin J. Sergeant, Tristan A. Cogan, Sergeant, Martin J., Chrystala Constantinidou, Tristan A. Cogan (200496), Mark J. Pallen (8904), Cogan, Tristan A., Penn, Charles W., Pallen Mark J., Martin J Sergeant, Michael R. Bedford (541021), Cogan Tristan A.   +33 more
core   +1 more source

Establishing genetic manipulation for novel strains of human gut bacteria [PDF]

, 2023
Recent years have seen the development of high-accuracy and high-throughput genetic manipulation techniques, which have greatly improved our understanding of genetically tractable microbes.
Sheridan, Paul O, Scott, Karen P., Odat, Ma’en Al, Sheridan, Paul O.   +3 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A review of 10 years of human microbiome research activities at the US National Institutes of Health, Fiscal Years 2007-2016

, 2019
The National Institutes of Health (NIH) is the primary federal government agency for biomedical research in the USA. NIH provides extensive support for human microbiome research with 21 of 27 NIH Institutes and Centers (ICs) currently funding this area ...
NIH Human Microbiome Portfolio Analysis Team
core   +1 more source

Structure, function and diversity of the healthy human microbiome [PDF]

, 2011
Author Posting. © The Authors, 2012. This article is posted here by permission of Nature Publishing Group. The definitive version was published in Nature 486 (2012): 207-214, doi:10.1038/nature11234.Studies of the human microbiome have revealed that ...
Friedman, Jonathan, Human Microbiome Project Consortium, Alm, Eric J., Smillie, Christopher S.   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A systematically biosynthetic investigation of lactic acid bacteria reveals diverse antagonistic bacteriocins that potentially shape the human microbiome [PDF]

, 2023
Background Lactic acid bacteria (LAB) produce various bioactive secondary metabolites (SMs), which endow LAB with a protective role for the host. However, the biosynthetic potentials of LAB-derived SMs remain elusive, particularly in their diversity ...
Chenchen Feng, Kalimuthu, S, Bei-bei He, Dengwei Zhang, Jing Liu, Yong-Xin Li, Zhang, DW, Zheng Zhong, Cai, PY, Feng, CC, Neelakantan, P, He, BB, Jian Zhang, Liu, J, Zhong, Z, Song, ZM, Shanthini Kalimuthu, Zhi-Man Song, Peiyan Cai, Li, YX, Prasanna Neelakantan, Zhang, J   +21 more
core   +1 more source

Analysis and Interpretation of the Human Microbiome [PDF]

Inflammatory Bowel Diseases, 2016
Microbiome research has experienced an unprecedented level of growth over the last decade. This is largely due to revolutionary developments in, and accessibility to, DNA sequencing technologies that have enabled laboratories with even modest budgets to undertake projects.
Ashton, James, Beattie, R. Mark, Ennis, Sarah, Cleary, David   +3 more
openaire   +4 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source