Results 71 to 80 of about 23,384 (208)

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

, 2023
The study of the human microbiome is a multidisciplinary area ranging from the field of technology to that of personalized medicine. The possibility of using microbiota biomarkers to improve the diagnosis and monitoring of diseases (e.g., cancer), health
Araceli González-Cortés, Sánchez Tirado, Esther, Campuzano Ruiz, Susana, González-Cortés, Araceli, Esther Sánchez-Tirado, Agüí, Lourdes, Paloma Yáñez-Sedeño, Campuzano, Susana, Pingarrón, José Manuel, José Manuel Pingarrón, Susana Campuzano, González Cortés, Araceli, Pingarrón Carrazón, José Manuel, Yáñez-Sedeño Orive, Paloma, Yáñez-Sedeño, Paloma, Sánchez-Tirado, Esther, Lourdes Agüí, Agüí Chicharro, María Lourdes   +17 more
core   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Human milk microbiota: what did we learn in the last 20 years?

, 2022
Human milk (HM) is the gold standard for infant nutrition during the first months of life. Beyond its nutritional components, its complex bioactive composition includes microorganisms, their metabolites, and oligosaccharides, which also contribute to gut
Collado, Maria Carmen, Bäuerl, Christine, Cabrera-Rubio, Raul, Esteban-Torres, Maria, Selma-Royo, Marta, Calvo-Lerma, Joaquim   +5 more
core   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

First encounters of the microbial kind: perinatal factors direct infant gut microbiome establishment

, 2022
The human gut microbiome harbors a diverse range of microbes that play a fundamental role in the health and well-being of their host. The early-life microbiome has a major influence on human development and long-term health.
Ross, R. Paul, Linehan, Kevin, Stanton, Catherine, Ryan, C. Anthony, Dempsey, Eugene M.   +4 more
core  

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model [PDF]

, 2008
The transgenomic metabolic effects of exposure to either Lactobacillus paracasei or Lactobacillus rhamnosus probiotics have been measured and mapped in humanized extended genome mice (germ-free mice colonized with human baby flora).
Martin, F. P. J., Martin, F.P.J., LindOn, J.C., Kochhar, S., Holmes, E., Sprenger, N, Fay, L. B., Lindon, J. C., Rochat, F., Kochhar, S, Rezzi, S., Jeremy K Nicholson, Serge Rezzi, Ivan K S Yap, Nicholson, J. K., Rezzi, S, Nicholson, J.K., Ramadan, Z, Laurent B Fay, Yap, IKS, Sunil Kochhar, Yap, K.S., Yulan Wang, Ramadan, Z., Torbjörn Lundstedt, Francois‐Pierre J Martin, Cherbut, C., Wang, Y., Holmes, E, Martin, F-PJ, Peter van Bladeren, Lundstedt, Torbjörn,, Lindon, JC, Ziad Ramadan, John C Lindon, Norbert Sprenger, Fay, L.B., Sprenger, N., Lek, P, Lundstedt, T, Fay, LB, Wang, Y, Yap, I. K. S., Elaine Holmes, Per Lek, Lek, P., van Bladeren, P., Peré-Trepat, E., Nicholson, JK, Bladeren, P.J., van, van Bladeren, P   +50 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source