Results 61 to 70 of about 23,384 (208)
Advanced Science, EarlyView.This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia +5 more
wiley +1 more source
Characterizing microbiome changes in the graduate student gut [PDF]
, 2016 Dysbiosis of the human microbiome is linked to human health problems, and as such, is a main concern of anthropological microbiome research. Analysis of how microbiomes change over time and under stress may reveal trends that lead to dysbiotic states ...
Lund, Justin
core
Advanced Science, EarlyView.A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min +6 more
wiley +1 more source
Advanced Science, EarlyView.An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao +11 more
wiley +1 more source
Bioinformatics for the Human Microbiome Project
PLoS Computational Biology, 2012 Microbes inhabit virtually all sites of the human body, yet we know very little about the role they play in our health. In recent years, there has been increasing interest in studying human-associated microbial communities, particularly since microbial dysbioses have now been implicated in a number of human diseases [1]–[3].
Dirk Gevers +3 more
openaire +7 more sources
Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome
Advanced Science, EarlyView.We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu +19 more
wiley +1 more source
Role of Human Oral Microbiome in Diseases
The human oral microbiome represents a diverse and intricate ecosystem comprising bacteria, fungi, viruses, and protozoa. It plays a vital role in numerous physiological processes, ranging from digestion to immunity.
Vijay Kumar Sinhal +6 more
core +1 more source
EVALUATING PREDICTIVE METABOLIC MODELLING TOOLS USING MICROBIOME SEQUENCING-METABOLOMIC DATA
, 2021 Metabolomic technologies have been utilized increasingly in tandem with sequencing technologies in microbiome studies. Combined microbiome-metabolome approaches have fueled the discovery of many convincing associations between disease-associated ...
Tang, Chris
core
Advanced Science, EarlyView.Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang +32 more
wiley +1 more source
High throughput methods for the investigation of the human microbiome
, 2011 Microorganisms can colonise many sites within the human host, including the skin, gastrointestinal tracts, oronasopharyngeal cavity and urogenital tract. Comprehensive studies of the human microbiome often need to encompass a large number of samples as a
Lau, Kelvin +3 more
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