Results 261 to 270 of about 1,184,319 (326)
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao+17 more
wiley +1 more source
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang+14 more
wiley +1 more source
Bridging the Milk Gap: Integrating a Human Milk Bank-Blood Bank Model to Reinforce Lactation Support and Neonatal Care. [PDF]
Barin J+13 more
europepmc +1 more source
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang+9 more
wiley +1 more source
Characterising the Human Milk Microbiota of Indian Mothers: Prospects for Probiotic Discoveries and Antimicrobial Peptides. [PDF]
Anil H+9 more
europepmc +1 more source
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang+9 more
wiley +1 more source
"OMICS" in Human Milk: Focus on Biological Effects on Bone Homeostasis. [PDF]
Farella I+7 more
europepmc +1 more source