Results 21 to 30 of about 515,553 (312)

Impact of Intestinal Microbiota on Cognitive Flexibility by a Novel Touch Screen Operant System Task in Mice

Frontiers in Neuroscience, 2022
Cognitive flexibility is the ability to rapidly adapt to a constantly changing environment. It is impaired by aging as well as in various neurological diseases, including dementia and mild cognitive impairment.
Hazuki Tamada, Kayo Ikuta, Yusuke Makino, Daisuke Joho, Takeru Suzuki, Masaki Kakeyama, Masaki Kakeyama, Mitsuharu Matsumoto, Mitsuharu Matsumoto   +8 more
doaj   +1 more source

Does neonatal ankyloglossia interfere in the growth of infants during the first 6 months of life? A case series nested in a cohort study

Journal of Medical Case Reports, 2022
Background Ankyloglossia is commonly reported as one of the major causes of breastfeeding difficulty. There is a lack of research on infant growth and latching performance with clinical measures.
Christyann Lima Campos Batista, Alex Luiz Pozzobon Pereira   +1 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Effect of Holder pasteurization on nutrient and immune component retention in human milk: a comparison between water and dry pasteurizers

International Breastfeeding Journal
Background Holder pasteurization (HoP; 62.5 °C, 30 min) is the method used most frequently in human milk banks to reduce the risk of infection transmission through donor human milk (DHM), but it has the disadvantage of potentially affecting the contents ...
Miori Tanaka, Midori Date, Kasumi Takayama, Nagisa Matsuura, Katsumi Mizuno   +4 more
doaj   +1 more source

Emergency response and preparedness among Polish human milk banks: a comparison of the COVID-19 pandemic and the 2022 Ukrainian refugee crisis

Frontiers in Nutrition
IntroductionIn recent years, Poland has faced two major emergencies: the COVID-19 pandemic, a global-scale public health emergency in 2020, and the outbreak of a full-scale war in Ukraine, which forced over 9 million Ukrainians–mostly women and children ...
Małgorzata Gawrońska, Małgorzata Gawrońska, Elena Sinkiewicz-Darol, Elena Sinkiewicz-Darol, Elena Sinkiewicz-Darol, Aleksandra Wesołowska, Aleksandra Wesołowska   +6 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

New latex agglutination assay for the determination of lactoferrin in human milk

International Breastfeeding Journal
Background Lactoferrin (LF) in human milk has various biological properties and contributes to the prevention of preterm birth complications. Enzyme-linked immunosorbent assay (ELISA) is one of the most commonly used methods to measure LF in human milk ...
Miori Tanaka, Midori Date, Katsumi Mizuno   +2 more
doaj   +1 more source

Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study

Frontiers in Systems Neuroscience, 2013
Recent studies suggest that intestinal microbiota influences gut-brain communication. In this study, we aimed to clarify the influence of intestinal microbiota on cerebral metabolism. We analyzed the cerebral metabolome of germ-free (GF) mice and ex-germ-
Mitsuharu eMatsumoto, Ryoko eKibe, Takushi eOoga, Yuji eAiba, Emiko eSawaki, Yasuhiro eKoga, Yoshimi eBenno   +6 more
doaj   +1 more source

Quantification of phospholipids and glycerides in human milk using ultra-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry

Frontiers in Chemistry, 2023
Human milk lipids, which are an important source of energy and affect growth and development of infants, require a comprehensive method for its qualitative and quantitative analysis.
Yan Liu, Yan Liu, Weicang Qiao, Weicang Qiao, Yanpin Liu, Yanpin Liu, Junying Zhao, Junying Zhao, Qian Liu, Qian Liu, Kai Yang, Kai Yang, Minghui Zhang, Minghui Zhang, Yaling Wang, Yaling Wang, Yan Liu, Yan Liu, Lijun Chen, Lijun Chen   +19 more
doaj   +1 more source