Results 51 to 60 of about 1,240,536 (340)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Receiving screened donor human milk as part of a community‐based lactation support programme reduces parental symptoms of anxiety and depression

Maternal and Child Nutrition
Infant feeding decisions and maternal mental health are closely tied. Donor human milk (DHM) protects premature infant health and development and can reduce hospital stays.
Amy Brown, Sam Griffin, Gillian Weaver, Natalie Shenker   +3 more
doaj   +1 more source

Enhanced versus standard fortification of pasteurized donor human milk for growth in very low birth weight infants: a randomized controlled trial

Frontiers in Nutrition
IntroductionVery-low-birthweight (VLBW) infants on pasteurized donor human milk (PDHM) have poorer growth compared to infants on fortified mother's milk, suggesting that standard fortification methods for PDHM are inadequate.MethodsWe designed a ...
Chengsi Ong, Anng Anng Wong, Siew Tin Wong, Ying Zheng, Cynthia Pui Chan Pang, Cynthia Pui Chan Pang, Pooja Agarwal Jayagobi, Pooja Agarwal Jayagobi, Joo Guan Yeo, Joo Guan Yeo, Joo Guan Yeo, Kee Thai Yeo, Kee Thai Yeo, Mei Chien Chua, Mei Chien Chua, Mei Chien Chua   +15 more
doaj   +1 more source

Human milk‐sharing practices and infant‐feeding behaviours: A comparison of donors and recipients [PDF]

, 2022
Jennifer Peregoy, Giovana M. Pinheiro, Sheela R. Geraghty, Katherine L. Dickin, Kathleen M. Rasmussen   +4 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Sequencing the transcriptome of milk production: milk trumps mammary tissue [PDF]

, 2013
Background: Studies of normal human mammary gland development and function have mostly relied on cell culture, limited surgical specimens, and rodent models.
Barry, Peter A, German, J Bruce, Hartono, Stella R, Hinde, Katie, Hovey, Russell C, Islas-Trejo, Alma, Korf, Ian, Lee, Joyce WS, Lemay, Danielle G, Medrano, Juan F, Schmidt, Kimberli A, Silva, Pedro Ivo, Smilowitz, Jennifer T, Ventimiglia, Frank   +13 more
core   +2 more sources

Whey-derived peptides interactions with ACE by molecular docking as a potential predictive tool of natural ACE inhibitors [PDF]

, 2020
Several milk/whey derived peptides possess high in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. However, in some cases, poor correlation between the in vitro ACE inhibitory activity and the in vivo antihypertensive activity has been ...
Chamata, Yara, Jauregi, Paula, Watson, Kimberly A.   +2 more
core   +1 more source

Bovine milk with variant β-casein types on immunological mediated intestinal changes and gut health of mice

Frontiers in Nutrition, 2022
Dietary proteins provide bioactive peptides, which are important for host gastrointestinal functions. We hypothesized that A2-type β-casein could provide gastrointestinal benefits and improve the immune and gut health.
Bin Liu, Bin Liu, Weicang Qiao, Weicang Qiao, Minghui Zhang, Minghui Zhang, Yanpin Liu, Yanpin Liu, Junying Zhao, Junying Zhao, Lijun Chen, Lijun Chen   +11 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source