Chapter 16: Prophylactic Human Papillomavirus Vaccines [PDF]
JNCI Monographs, 2003 Candidate prophylactic vaccines based on papillomavirus L1 virus-like particles (VLPs) are currently in human clinical trials. The main long-term goal of the vaccine is to reduce the incidence of cervical cancer and its precursors. In animal papillomavirus models, systemic immunization with L1 VLPs can induce high titers of neutralizing antibodies that
Lowy, Douglas R., Frazer, Ian H.
openaire +4 more sources
Human papillomavirus 16 infection in adenocarcinoma of the cervix [PDF]
British Journal of Cancer, 2005 The impact of the success of organised cervical screening programme results in a steady decline of the incidence of squamous cell carcinoma of the cervix but a concomitant increase in the incidence of the less common histological subtypes, particularly adenocarcinoma of the cervix (ACC). Although Human papillomavirus (HPV) infection is believed to be a
Chew, G K +5 more
openaire +2 more sources
E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I [PDF]
, 2005 Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium.
Marchetti, Barbara +9 more
core +1 more source
A Longitudinal Study of Human Papillomavirus 16 L1, E6, and E7 Seropositivity and Oral Human Papillomavirus 16 Infection [PDF]
Sexually Transmitted Diseases, 2015 Individuals with human papillomavirus (HPV) infections can develop IgG antibodies to HPV proteins including the L1 capsid and E6 and E7 oncoproteins. Evidence on whether L1 antibodies reduce the risk of cervical HPV infection is mixed, but this has not been explored for oral HPV infections.
Beachler, Daniel C +12 more
openaire +4 more sources
Human papillomavirus (HPV) 16 infection is not detected in rectal carcinoma
Infectious Agents and Cancer, 2020 Introduction Persistence of human papillomavirus (HPV) infections is associated with squamous cell carcinomas of different human anatomic sites. Several studies have suggested a potential role for HPV infection, particularly HPV16 genotype, in rectal ...
Sandra F. Martins +3 more
doaj +1 more source
Genotyping test based on viral DNA, RNA or both as a management option for high-risk human papillomavirus positive women: a cross sectional study [PDF]
Medicinski Glasnik, 2019 Aim This cross-sectional study of a group of women with abnormal cytology and high-risk human papillomavirus (hrHPV) infection compared genotyping HPV DNA and mRNA assays according to two age categories of women (S1: ≤30 and S2: >30 years). Methods The
Irma Salimović-Bešić +2 more
doaj +1 more source
E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domai [PDF]
, 2006 Human papillomavirus type 16 E5 protein (HPV-16 E5) is expressed early in papillomavirus infection and is localised primarily in the cell Golgi apparatus (GA) and endoplasmic reticulum. E5 prevents transport of the major histocompatibility class I (MHC I;
Marchetti, Barbara +7 more
core +1 more source
Human papillomavirus type 16 E6 induces cell competition.
PLoS Pathogens, 2022 High-risk human papillomavirus (HPV) infections induce squamous epithelial tumors in which the virus replicates. Initially, the virus-infected cells are untransformed, but expand in both number and area at the expense of uninfected squamous epithelial ...
Nicole Brimer, Scott Vande Pol
doaj +1 more source
Cervical human papillomavirus infection and squamous intraepithelial lesions in rural Gambia, West Africa: viral sequence analysis and epidemiology. [PDF]
, 2005 The development of effective strategies against cervical cancer in Africa requires accurate type specific data on human papillomavirus (HPV) prevalence, including determination of DNA sequences in order to maximise local vaccine efficacy.
Gelder, CM +32 more
core +1 more source
Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru
Brazilian Journal of Infectious Diseases, 2014 Background: Molecular tests allow the detection of high-risk human papillomavirus in cervical samples, playing an important role in the prevention of cervical cancer.
Ricardo Iwasaki +3 more
doaj +1 more source