Results 31 to 40 of about 116,541 (310)

Thermostable Bioluminescent Intercalating Dyes for Real‐Time, Integrated Nucleic Acid Amplification and Detection

Angewandte Chemie, EarlyView.
We present a bioluminescent diagnostic platform that integrates DNA amplification and detection in a single step. The engineering of thermostable luciferase‐intercalating dye conjugates and controlled release of caged luciferin substrates enable real‐time, detection of attomolar concentrations of viral DNA within 30 min.
Yosta de Stigter, Harmen J. van der Veer, Sterre de Lignie, Robbert J. de Haas, Renko de Vries, Joost P. H. Schoeber, Anne J. M. Loonen, Adriaan J. C. van den Brule, Maarten Merkx   +8 more
wiley   +2 more sources

Better or Worse? The Independent Prognostic Role of HPV-16 or HPV-18 Positivity in Patients With Cervical Cancer: A Meta-Analysis and Systematic Review

Frontiers in Oncology, 2020
Background: The literature reports conflicting results regarding the effect of human papillomavirus (HPV) genotype 16 (HPV-16)/18 (HPV-18) positivity on cervical cancer (CC) prognosis.Aim: To conduct a meta-analysis to examine the effect of HPV-16/18 ...
Xing Chen, Ping Zhang, Shanshan Chen, Hanxiao Zhu, Kai Wang, Liya Ye, Jun Wang, Junhui Yu, Shuangshuang Mei, Zhengrong Wang, Xiaodong Cheng   +10 more
doaj   +1 more source

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources

Suppression of Stromal Interferon Signaling by Human Papillomavirus 16 [PDF]

Journal of Virology, 2019
The persistence of high-risk human papillomavirus (HPV) infections is the key risk factor for developing HPV-associated cancers. The ability of HPV to evade host immunity is a critical component of its ability to persist. The environment surrounding a tumor is increasingly understood to be critical in cancer development, including immune evasion.
Gaurav Raikhy, Brittany L. Woodby, Matthew L. Scott, Grace Shin, Julia E. Myers, Rona S. Scott, Jason M. Bodily   +6 more
openaire   +2 more sources

Human papillomavirus 16 is an aetiological factor of scrotal cancer [PDF]

British Journal of Cancer, 2017
Squamous cell scrotal carcinoma (SCSC) is an infrequent skin cancer associated historically with occupational carcinogens. Human papillomavirus (HPV) DNA has been associated with SCSC but there is no definitive proof of its oncogenic role.Human papillomavirus-DNA and -E6*I mRNA were analysed in six invasive histologically typed SCSC.
Guimerà, Núria, Alemany i Vilches, Laia, Halec, Gordana, Pawlita, Michael, Wain, Gerard Vincent, Salas Vailen, José Santos, Azike, Jerome E., Jenkins, David, Sanjosé Llongueras, Silvia de, Quint, Wim, Bosch, F. Xavier   +10 more
openaire   +3 more sources

The Role of the Human Papillomavirus (HPV) in Cervical Cancer: A Review about HPV-Induced Carcinogenesis and Its Epidemiology, Diagnosis, Management and Prevention

International Journal of Medical Students, 2016
The human papillomavirus (HPV) was the first virus known to induce carcinogenesis and is associated with cancers of the uterine cervix, anogenital tumors and malignancies of the head and neck.
Karl Bonello, Renald Blundell
doaj   +1 more source

Life cycle heterogeneity in animal models of human papillomavirus-associated disease

, 2002
Animal papillomaviruses are widely used as models to study papillomavirus infection in humans despite differences in genome organization and tissue tropism. Here, we have investigated the extent to which animal models of papillomavirus infection resemble
Peh, W.L., Liu, W.J., Christensen, N., Egawa, K., Lewis, J., Christensen, Neil, Peh, Woei Ling, Egawa, Kiyofumi, Percival, Alan, Lewis, Jon, Liu, Wen Jun, Percival, A., Nicholls, Philip, Doorbar, J., Brandsma, Janet, Middleton, K., Nicholls, P.K., Brandsma, J., Middleton, Kate, Sotlar, Karl, Sotlar, K., Doorbar, John   +21 more
core   +1 more source

Papillomavirus E5: the smallest oncoprotein with many functions [PDF]

, 2011
Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the ...
Roperto, S., Borzacchiello, G., Venuti Aldo, Sante Roperto, Corteggio, A., BORZACCHIELLO, GIUSEPPE, Giuseppe Borzacchiello, Roperto Sante, CORTEGGIO, ANNUNZIATA, Francesca Paolini, Nasir, L., A. Venuti, Paolini Francesca, Aldo Venuti, Paolini, F., L. Nasir, Lubna Nasir, Annunziata Corteggio, Corteggio Annunziata, F. Paolini, Borzacchiello Giuseppe, ROPERTO, SANTE, M.S. Campo, Maria S Campo, Nasir Lubna, Venuti, A., Campo, M.S., Campo Maria S   +27 more
core   +1 more source

Comparative Analysis of HPV16 Variants in the Untranslated Regulatory Region, L1, and E6 Genes among Vaccinated and Unvaccinated Young Women: Assessing Vaccine Efficacy and Viral Diversity

Viruses
HPV16 is occasionally detected in vaccinated women who received the bivalent HPV16/18 vaccine, usually at low viral loads. This study explored potential differences in HPV16 variants between vaccinated and unvaccinated women.
Kahren van Eer, Tsira Dzebisasjvili, Renske D. M. Steenbergen, Audrey J. King   +3 more
doaj   +1 more source

Identification of a transforming gene of human papillomavirus type 16 [PDF]

Journal of Virology, 1989
Previously, we observed sequential two-step alteration, growth stimulation, and progression to a more malignant state in NIH 3T3 cells transfected by human papillomavirus type 16 (HPV-16) DNA. In this study, we prepared a cDNA library from RNA extracted from cells transfected with the HPV-16 DNA and isolated cDNA clones which had growth-stimulating ...
A, Tanaka, T, Noda, H, Yajima, M, Hatanaka, Y, Ito   +4 more
openaire   +2 more sources