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Molecular Mechanism of Carcinogenesis by Human Papillomavirus‐16

The Journal of Dermatology, 2000
AbstractHuman papillomaviruses (HPVs) are common DNA viruses in humans. Recently, epithelial cancers associated with HPV infection have been used as models of virus‐induced carcinogenesis. HPVs can be divided into two groups, mucosal and cutaneous. HPV‐16 is the most frequent mucosal type associated with cervical cancer.
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Detection of Human Papillomavirus 16 Transcription in Human Prostate Tissue

Journal of Urology, 1993
Previously we demonstrated human papillomavirus type 16 DNA in a high proportion of benign hyperplastic (BPH) and cancerous (CaP) prostate specimens using the polymerase chain reaction (PCR). While these data designate the prostate as a possible reservoir for sexual transmission of HPV, an etiological role for the virus in prostatic neoplasia is ...
J G, Dodd, M, Paraskevas, P J, McNicol
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Human Papillomavirus Type 16 and Early Cervical Neoplasia

New England Journal of Medicine, 1984
Flat warts (condylomata) of the uterine cervix are sometimes cytologically atypical and have abnormal mitotic figures; they are thought to be possible precursors of cancer of the cervix. Flat warts are caused by any of a number of types of human papillomaviruses (HPVs), one of which (HPV 16) has been previously associated with invasive cancer of the ...
C P, Crum   +3 more
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Human papillomavirus type 16 E5 protein (review)

International Journal of Oncology, 1997
The association of certain human papillomavirus (HPV) types with malignancies of the anogenital tract is well established. The virus type most frequently associated with cellular transformation is HPV 16, as has been shown in epidemiological studies. Its transforming capacity has also been demonstrated in many in vitro cell transformation experiments ...
E, Auvinen   +3 more
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Nucleotide polymorphisms of the human papillomavirus 16 E1 gene

Archives of Virology, 2013
The E1 ORF is one of the most conserved regions in the human papillomavirus (HPV) genome. The complete E1 gene of the HPV16 genome was amplified with four overlapping primer sets in 16 high-grade (CIN II, III) and 13 low-grade cervical (CIN I) intraepithelial neoplasias as well as in one cervical cancer case.
D, Tsakogiannis   +7 more
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Detection of Human Papillomavirus Type 16 in Plasma Cells

Gynecologic Oncology, 1993
Chronic benign plasma cell tumor of the cervix, also called chronic plasma cell cervicitis, is a rare disease of unknown etiology, characterized by a heavy infiltration of plasma cells forming granulation tissue. To identify infectious agents associated with this disease, we extracted and analyzed DNA from the 17-year-old paraffin section of the ...
D, Payne   +4 more
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Seroprevalence of Human Papillomavirus Type 16 in Pregnant Women

Obstetrics & Gynecology, 1999
To determine the seroprevalence of and risk factors for human papillomavirus (HPV) type 16 capsid antibodies in a large cohort of pregnant women.Antibodies against in vitro produced HPV-16 capsids were measured in stored sera from 2597 pregnant women enrolled from 1984 through 1989 in the Vaginal Infection and Prematurity Study, New Orleans site.Women ...
M E, Hagensee   +5 more
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Human papillomavirus 6, 11, and 16 in laryngeal papillomas

The Journal of Pathology, 1991
AbstractTwenty‐seven cases of benign laryngeal papillomas, both single and multiple variants, were analysed for human papilomavirus (HPV) by DNA slot‐blot hybridization chiefly to determine the pattern of infection in Hong Kong Chinese. DNA was extracted from paraffin blocks of formalin‐fixed tissue and probed separately for HPV 6, 11, 16, and 18 ...
Loke, SL   +3 more
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Modelling of the human papillomavirus type 16 E5 protein

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2002
The product of the E5 oncogene in human papillomaviruses (HPVs) participates in cellular transformation. The sequences of E5 from high-risk HPV types are closely related, and the ability to transform is thought to be associated with their structure.
Angel, Alonso, Jennifer, Reed
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Human papillomavirus type 16 variant assignment by pyrosequencing

Journal of Virological Methods, 2006
Polymorphisms in human papillomavirus type 16 (HPV16) result in variants from the prototype sequence which can be designated according to geographic distribution and are broadly classified as European (E), African (Af), Asian (As), or Asian-American (AA). Detection of variants has been used to distinguish persistent HPV16 infection from re-infection in
David C, Swan   +4 more
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