Results 201 to 210 of about 8,144,169 (239)

Nomenclature of human platelet antigens

Vox Sanguinis, 2003
V Kiefel, R Kekomäki, N A Watkins
exaly   +3 more sources

Human platelet antigens frequencies in Maori and Polynesian populations

Transfusion Medicine, 2013
SUMMARYBackgroundAllele frequencies of human platelet antigens (HPA) reflect population history and possibility of platelet‐specific alloimmunization. Here, we report on screening of variants at HPA loci for Polynesian and Maori subjects.ObjectivesOur aims are to evaluate new HPA genotyping methods, compile and analyse new HPA datasets for these ...
Edinur, H., J Dunn, P., Lea, Rodney, hambers, G.   +3 more
openaire   +4 more sources

Status of the MNSs antigens on human platelets

Transfusion, 1987
A sensitive and specific radioimmunoassay was used to determine whether human platelets possess antigens of the MNSs blood group. Mouse monoclonal IgG anti‐M and anti‐N were purified by Staphylococcus protein A chromatography, labeled with 125I, and incubated with platelet pellets from donors of various MN phenotypes. Human IgG anti‐ M, ‐S, and ‐s were
M B, Simpson, R A, Dunstan, W F, Rosse, A C, Munro, R, Fraser, M E, Nichols   +5 more
openaire   +2 more sources

Molecular Genetics of Human Platelet Antigens

Infusionstherapie und Transfusionsmedizin / Infusion Therapy and Transfusion Medicine, 2009
The purpose of this article is to review the molecular genetics of human platelet antigens, the application of molecular biological techniques to detect mutations underlying polymorphisms and the importance of these techniques for clinical medicine of immunemediated platelet destruction.
S, Simsek, A E, von dem Borne
openaire   +2 more sources

Antithrombin III Antigen in Human Platelets

Thrombosis and Haemostasis, 1985
SummaryImmunoreactive AT III was found in human platelets. AT III antigen was quantified in platelets taken from each of 17 healthy donors by a specific competitive enzyme immunoassay using purified AT III and AT III antibodies. AT III antigen levels in extracts of washed platelets disrupted by freezing and thawing ranged from 32 to 140 ng per 109 ...
M L, Alhenc-Gelas, M, Aiach, A, Gorenflot, J P, Andreaux   +3 more
openaire   +2 more sources

Human platelet antigen genotyping of platelet donors in southern Brazil

International Journal of Immunogenetics, 2015
SummaryHuman platelet antigens (HPA) are immunogenic structures that result from single nucleotide polymorphisms (SNPs) leading to single amino acid substitutions. This study sought to determine the allele and genotype frequencies of HPA‐1, HPA‐2, HPA‐3, HPA‐4, HPA‐5 and HPA‐15 in platelet donors from the state of Rio Grande do Sul (RS), Brazil, and ...
J. Merzoni, I. S. Fagundes, L. W. Lunardi, J. D.‐R. Lindenau, B. C. Gil, M. Jobim, V. G. Dias, L. Merzoni, L. Sekine, T. G. H. Onsten, L. F. Jobim   +10 more
openaire   +2 more sources

Lea Blood Group Antigen on Human Platelets

American Journal of Clinical Pathology, 1985
One- and two-stage radioligand assays were used to determine if human platelets possess the Lea antigen. Goat IgG anti-Lea antibody was purified by multiple adsorptions with Le(a-b-) human red blood cells, followed by affinity chromatography with synthetic Lea substance and labeling with 125I.
R A, Dunstan, M B, Simpson, W F, Rosse
openaire   +2 more sources

Human Leukocyte Antigen Alloimmunization and Alloimmune Platelet Refractoriness

Transfusion Medicine Reviews, 2020
Despite significant advancements in the production of platelet products, storage, and transfusion, transfusion refractoriness remains a significant clinical problem, affecting up to 14% of hematological patients receiving platelet transfusions. Human leukocyte antigen (HLA) alloimmunization is a major cause of immune platelet refractoriness, and its ...
Anno, Saris, Katerina, Pavenski
openaire   +2 more sources

Quantification of human platelet antigen‐1a antibodies with the monoclonal antibody immobilization of platelet antigens procedure

Transfusion, 2005
BACKGROUND: Fetal‐neonatal alloimmune thrombocytopenia results from a maternal alloimmunization against fetal platelet (PLT) antigens. In Caucasian persons, human PLT antigen‐1a (HPA‐1a) is the most frequently implicated antigen. Our aim was to develop a method supported by a mathematical approach to quantify HPA‐1a antibodies.STUDY DESIGN AND METHODS:
Gérald, Bertrand, Vincent, Jallu, Maxime, Gouet, Killie Mette, Kjaer, Patrick, Lambin, Anne, Husebekk, Cécile, Kaplan   +6 more
openaire   +2 more sources

Antigens of Human Trophoblast: Trophoblast‐Lymphocyte Cross‐Reactive Antigens on Platelets*

American Journal of Reproductive Immunology and Microbiology, 1987
ABSTRACT: Human and rabbit antibodies to trophoblast‐lymphocyte cross‐reactive (TLX) antigens were employed in an enzyme‐linked immunosorbent assay (ELISA) to identify and characterize the TLX alloantigen system on human platelets. Neither washing nor extraction in chaotrope or acid altered platelet TLX.
T, Kajino, W P, Faulk, J A, McIntyre
openaire   +2 more sources