Results 211 to 220 of about 8,144,169 (239)

Establishment of reference panel for human platelet antigen genotyping

Vox Sanguinis, 2014
Background and ObjectivesHuman platelet antigens (HPAs) are platelet‐specific alloantigens associated with polymorphisms of platelet surface glycoproteins (GPs), and they can induce alloantibodies when individuals lacking a particular polymorphism are exposed to them via pregnancy or transfusion.
R S, Li, Z L, Qiao, B, Ling, P, Lu
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Frequency distribution of human platelet antigens in the Indian population

Transfusion Medicine, 2005
summary.  This study was undertaken with an aim of establishing the frequency distribution of various human platelet antigens (HPA) in Indian populations by means of DNA‐based technology. A total of 1164 people belonging to various population groups were studied for the frequency distribution of HPA.
B, Kulkarni, D, Mohanty, K, Ghosh
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Retention of HLA Antigens on Previously Frozen Human Platelets

Transfusion, 1980
Recent technical achievements allow satisfactory cryopreservation of human platelets that, after thawing and washing, maintain functional viability for therapeutic use. We have now demonstrated that such previously frozen platelets retain full HLA antigenic activity in spite of the combination of freezing, thawing, and washing procedures and the ...
M S, Pollack, C G, Zaroulis, J, Klainbard, I Z, Leiderman, B, Dupont   +4 more
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Human platelet‐specific antigen frequencies in Indonesian population

Transfusion Medicine, 2013
SUMMARYBackgroundAlloantibodies against human platelet antigens (HPAs) are responsible for the development of alloimmune thrombocytopenia including platelet transfusion refractoriness (PTR) and neonatal alloimmune thrombocytopenia (NAIT). Therefore, transfusion of HPA‐compatible platelets is of importance for the management of these diseases ...
, Asmarinah, R, Dharma, N K, Ritchie, S, Rahayu, E, Putricahya, S, Santoso   +5 more
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Human Platelet Antigen Gene Frequencies in the Austrian Population

Haemostasis, 2009
Gene frequencies for the human platelet antigen systems HPA-1, -2, -3, and -5 were determined directly from DNA isolated from cord blood of more than 900 randomly selected Caucasoid newborns in Vienna, Austria. Genotyping was performed by specific amplification of the respective regions coding for platelet glycoproteins GP lb, IIb, IIIa, and la by PCR.
A, Holensteiner, S, Walchshofer, A, Adler, E M, Kittl, W R, Mayr, S, Panzer   +5 more
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Human platelet antigen‐1a antibodies induce the release of the chemokine RANTES from human platelets

Vox Sanguinis, 2001
Background and ObjectiveBinding of human platelet antigen‐1a (HPA‐1a)‐specific antibodies to target platelets can trigger platelet activation and mediator release. Here we tested the effect of HPA‐1a antibody‐containing sera on platelet release of the chemokine RANTES (regulated on activation, normal, T‐cell expressed, and presumably secreted) in vitro.
M, Dettke, M, Dreer, P, Höcker, S, Panzer   +3 more
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Genotyping of Human Platelet Antigens by BeadChip Microarray Technology

2015
Human platelet antigen (HPA) typing plays a critical role in the diagnosis of fetal/neonatal alloimmune thrombocytopenia, and the prevention of posttransfusion purpura and refractoriness to platelet transfusions. The recent development of high-throughput genotyping methods, allowing simultaneous genotyping of as many as 17 HPAs, is of utmost interest ...
Gerald, Bertrand, Fabiana, Conti
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Noninvasive fetal genotyping of human platelet antigen-1a.

BJOG : an international journal of obstetrics and gynaecology, 2011
We describe a reliable noninvasive fetal human platelet antigen (HPA)-1a genotyping assay on a real-time polymerase chain reaction (PCR) platform using cell-free fetal DNA isolated from maternal blood. Nonspecific amplification of maternal cell-free DNA is overcome by pre-PCR digestion of the cell-free DNA with the Msp1 restriction enzyme.
Scheffer, P.G., Soussan, A.A., Verhagen, O.J.H.M., Page-Christiaens, G.C.M.L., Oepkes, D., Haas, M. de, Schoot, C.E. van der   +6 more
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Platelet antigens. The role of human platelet alloantigens (HPA) in blood transfusion and transplantation

Transplant Immunology, 2002
In this review, we describe the platelet surface molecules with special focus on the polymorphic glycoproteins giving rise to the human platelet alloantigen (HPA) system. We list the platelet glycoprotein complexes GPIa/IIa, GPIIb/IIIa, GPIb/V/IX and some other molecules, the corresponding genes that encode them and we describe their polymorphisms as ...
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Human Platelet Antigens (HPA) and Human Neutrophil Antigens (HNA) and Their Clinical Significance

2018
This chapter describes the nomenclature of human platelet antigens (HPA) and human neutrophil antigens (HNA). It presents the common principles involved in the immunohaematology of red cells and the immunohaematology of platelets and granulocytes. The chapter then outlines the most important HPA and HNA.
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