Results 51 to 60 of about 2,363,697 (358)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
SA Journal of Industrial Psychology, 2016 Orientation: Qualitative research is marked by phenomenal growth and development over the years. Research purpose: This article aims to offer insight into the emerging qualitative methodologies used in the fields of Psychology, Industrial and ...
Sumari O'Neil, Eileen Koekemoer
doaj +1 more source
Human resources and artist management. [PDF]
, 2014 Abstract This chapter is about employing and being employed in the entertainment industries. It considers the context of this industry and then provides an introduction to the generic principles of human resource management, before applying these to the specific context of recruitment and employment in entertainment, while also exploring ...
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Emotional Works and Turnover Intention of Sri Lankan Nurses
Kelaniya Journal of Management, 2017 In the quest for the concept of emotional work, it is apparent that comparing to the international context there are much less research done in Sri Lanka.
M.K. Dinithi Padmasiri, A.M.T. Lakmali
doaj +1 more source
The Monitoring Method of Enterprise Human Resource Efficiency under the Smart City Management Mode [PDF]
, 2021 Dongjun Ma
openalex +1 more source
FEBS Open Bio, EarlyView.This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li +10 more
wiley +1 more source
Gen Z’s enduring commitment to fitness apps: a comprehensive examination
Cogent Business & ManagementThis study investigates the sustained engagement of Generation Z with fitness apps using the Theory of Consumption Values (TCV) to identify the key determinants influencing this behaviour.
Vinod Sharma +4 more
doaj +1 more source
Impact of Employees’ Perceptions of Organizational Downsizing Practices on Their Commitment [PDF]
Kelaniya Journal of ManagementSri Lanka is presently facing with its most severe financial crisis in decades, with the building and construction sector being significantly affected. This study aims to investigate whether employees’ perceptions of organizational downsizing practices ...
M. D. K. Erandika, V. R. Ranasinghe
doaj +1 more source
Green Training and Development Practices on Environmental Sustainability: Evidence from Wamco PLC
Journal of Interdisciplinary Socio Economic and Community Study, 2022 Green training and development practices have been acknowledged as veritable tools for addressing environmental challenges; it is also a key ingredient for promoting the acceptance of environmental conservation in the workplace because in the long run ...
Tinuke Moradeke Fapohunda +2 more
doaj +1 more source