Results 101 to 110 of about 1,501,467 (321)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

Selecting and training candidates to suit their role

open access: yesCommunity Eye Health Journal, 2018
Training the eye team can improve individual and community eye health – provided the right people are trained, and in the right way.
Dhivya Ramsamy, Daksha Patel
doaj  

The Human Resources Strategic Management [PDF]

open access: yesRevista de Management Comparat International, 2009
The most of the specialists value the role of the strategies and the tactics in modern societies development, including in the economic field, especially in increasing the companies effectiveness, but also for mezo, macro and worldwide economic levels.
Emil Surlaru
doaj  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Case study: Encouraging nurses to develop skills and confidence in Indonesia

open access: yesCommunity Eye Health Journal, 2014
As part of Henny’s training in her new job, she was invited to take part in a training module on the early detection of eye disorders among children.
Widya Prasetyanti
doaj  

The role of the Allee effect in common-pool resource and its sustainability [PDF]

open access: yesarXiv
The management of common-pool resources is a complex challenge due to the risk of overexploitation and the tragedy of the commons. A novel framework has been introduced to address this issue, focusing on the coevolutionary relationship between human behavior and common-pool resources within a human-environment system.
arxiv  

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

open access: yesFEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang   +5 more
wiley   +1 more source

Human Resources for eye health: ensuring a smooth pipeline

open access: yesCommunity Eye Health Journal, 2018
Health workforce planning improves when activities in the education system align with labour market dynamics.
Daksha Patel
doaj  

A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers

open access: yesFEBS Open Bio, EarlyView.
We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei   +6 more
wiley   +1 more source

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