Results 71 to 80 of about 5,905,785 (344)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Identification of variables and their influence on the human resources planning in the territorial level

open access: yesJournal of Industrial Engineering and Management, 2016
Purpose: The purpose of this paper lies in the use of experimental way through empirical tools for identification of the set of variables and their interrelationships and influences on the human resources planning at the territorial level.
Rodobaldo Martínez Vivar   +3 more
doaj   +1 more source

Human Resources Strategy: The Era of Our Ways [PDF]

open access: yes, 2000
The purpose of this chapter is to discuss some of the main features and trends in human resources (HR) strategy. Inasmuch as people are among the most important resources available to firms, one could argue that HR strategy should be central to any ...
Shadur, Mark A.   +2 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

WHO ADOPT AND IMPLEMENT HUMAN RESOURCES STRATEGY IN AN ORGANIZATION? [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2016
The need for effective human resources strategies, which have a strong role in achieving goals has been a subject extensively treated in the literature. Thus, those interested in this field could learn about the stages of development of human resources
MUNTEANU ANCA-IOANA
doaj  

Mars climate engineering using orbiting solar reflectors [PDF]

open access: yes, 2009
The manned mission is seen as a first step towards a Mars surface exploration base-station and, later, establishing permanent settlement. The location and use of Mars's natural resources is vital to enable cost-effective long-duration human exploration ...
C. Sagan   +17 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

THE PERSONNEL STRATEGY AND PERSONNEL POLICIES DURING THE PANDEMIC [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2020
The human resources strategy encompasses change under the conditions of the COVID-19 health crisis. The change refers to new recruitment and selection procedures, new assessment standards, new approaches regarding promotion and motivation.
TOMESCU-DUMITRESCU CORNELIA, DAJU ELENA
doaj  

DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources [PDF]

open access: bronze, 2009
Helen V. Firth   +9 more
openalex   +1 more source

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