Results 61 to 70 of about 2,739,043 (309)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

An integrated national strategy for resource and environmental management in post-apartheid Namibia : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Development Studies at Massey University [PDF]

, 1995
This thesis presents a structure for integrated strategic planning across levels of government in Namibia. The study advocates necessary preconditions for the preparation of An Integrated National Strategy for Resource and Environmental Management in ...
Sikabongo, Frederick Mupoti
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The strategy of Madrasa Ibtidaiya Principal in human resource development for increasing teachers’ professional and academic competency

Mudarrisa: Jurnal Kajian Pendidikan Islam, 2018
The purposes of this research were to know the strategy of teachers’ professional development and to know teachers’ academic competence development conducted by the principal to the teachers of Madrasa Ibtidaiya (MI) in Wonosegoro Boyolali.
Muyiman Muyiman
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The elaboration of the strategic plan regarding human resources [PDF]

The elaboration of the plan constitutes a necessity for an organization which is governed by the desire to maintain the same objectives, that led to remarkable results; the factors’ generalization which influences positively the present situation of the ...
Cristina Maria Stoica
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Optimizing Madrasah Quality: A Strategic Approach to Human Resource Management

Al-Tanzim: Jurnal Manajemen Pendidikan Islam
This research analyzes human resource (HR) development strategies and their implications for quality management at Madrasah Aliyah Negeri (MAN) 1 Probolinggo. This research uses a qualitative case study type approach.
Fathurrahman Fathurrahman, Lailatul Fitriyah, Tsamar Nur Aini, Moses Adeleke Adeoye, Ahmad Muzakki Hakim   +4 more
doaj   +1 more source

Specific Elements of Marketing in the Recruitment and Selection of Human Resources Process in Romanian Army

Buletinul Ştiinţific al Academiei Trupelor de Uscat, 2018
The issue of recruiting a quality human resource appears to be, more or less, a universal one, and it is not just an issue for the United States of America but also for Europe, as the modern armies are confronting with difficulties in recruiting and ...
Alexandrescu Mihai-Bogdan
doaj   +1 more source

STRATEGIES AND POLICIES OF CRISIS HUMAN RESOURSES MANAGEMENT

Вестник университета, 2017
High relevance of the issues of crisis human resources management requires the formation of appropriate scientific and methodological tools. In this regard, based on the analysis of human resources management practices of Russian organizations in the ...
E. Mitrofanova, I. Esaulova
doaj   +1 more source