YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Sub-regional Meeting on Disability Legislation: Decent Work for Persons with Disabilities in Asia, UN Conference Centre, Bangkok, Thailand, 23-24 June 2008 [PDF]
, 2008 The Sub-regional Meeting on Disability Legislation, jointly organized by the ILO and the Office of the High Commissioner for Human Rights (OHCHR), took place in the framework of a technical cooperation project, “Promoting the Employability and Employment
ILO, Office of the High Commissioner for Human Rights (OHCHR) and Irish Aid
core +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Hamilton Human Rights Film Festival [PDF]
, 2014 This is the 1st Human Rights Film Festival in New Zealand since 2008, the Hamilton Human Rights Film Festival, was launched the weekend before WINTEC's School of Media Arts annual Arts Festival SPARK 2014.
Mandelberg, John
core
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Global Indigeneous People Political Movement in National Context of Indonesia: A Nationalism and Human Rights Approach [PDF]
, 2017 Andi Ismira
openalex +1 more source
Effectiveness of Labour Recruitment Regulation for the Protection of Human Rights for the Kenyan Migrant Domestic Workers [PDF]
, 2023 Grace Njambi Kimani, Weldon Ng’eno
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Tom Regan on Kind Arguments against Animal Rights and for Human Rights [PDF]
, 2015 Tom Regan argues that human beings and some non-human animals have moral rights because they are “subjects of lives,” that is, roughly, conscious, sentient beings with an experiential welfare.
Nobis, Nathan
core +1 more source