Results 61 to 70 of about 12,497,859 (378)

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

Are New Technologies an Aid to Reputation as a Disciplinarian?

open access: yesAJIL Unbound, 2019
Kristina Daugirdas offers a different vantage point from most scholarship on the accountability of international organizations (IOs) by examining whether a focus on reputation can address accountability deficits.
Lorna McGregor
doaj   +1 more source

Case report: change of dominant strain during dual SARS-CoV-2 infection

open access: yesBMC Infectious Diseases, 2021
Background The dual infection with SARS-CoV-2 is poorly described and is currently under discussion. We present a study of two strains of SARS-CoV-2 detected in the same patient during the same disease presentation.
Andrei E. Samoilov   +10 more
doaj   +1 more source

Reflective Hybrid Intelligence for Meaningful Human Control in Decision-Support Systems [PDF]

open access: yesarXiv, 2023
With the growing capabilities and pervasiveness of AI systems, societies must collectively choose between reduced human autonomy, endangered democracies and limited human rights, and AI that is aligned to human and social values, nurturing collaboration, resilience, knowledge and ethical behaviour.
arxiv  

A conversation on race (part 1): ‘the geographies of racism’ [PDF]

open access: yes, 2016
The following podcast episodes are the first in a three-week series on the LSE Human Rights Blog entitled ‘A Conversation on Race’
Human Rights, LSE
core  

Open Dialogue as a Human Rights-Aligned Approach

open access: yesFrontiers in Psychiatry, 2019
Throughout the last 20 years, the human rights perspective has increasingly developed into a paradigm against which to appraise and evaluate mental health care.
Sebastian von Peter   +6 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Depression and Anxiety among Iraqi Women: A Systematic Review

open access: yesErbil Journal of Nursing and Midwifery, 2018
Background and objective: Maternal mental health is considered an important subject among leading public health experts. Women are two to three times more likely to be diagnosed with mental illness compared to men.
Kathryn Mishkin   +3 more
doaj   +1 more source

Value Alignment, Fair Play, and the Rights of Service Robots [PDF]

open access: yesACM/AIES 2018, 2018
Ethics and safety research in artificial intelligence is increasingly framed in terms of "alignment" with human values and interests. I argue that Turing's call for "fair play for machines" is an early and often overlooked contribution to the alignment literature. Turing's appeal to fair play suggests a need to correct human behavior to accommodate our
arxiv   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

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