YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Concepts and features of international legal standards of human rights
, 2023 O.I. Nalyvaiko, N.A. Bratishko
openalex +2 more sources
The Equality and Human Rights Commission. Challenges and opportunities [PDF]
This report summarises the one-day workshop entitled 'The Equality and Human Rights Commission: Challenges and Opportunities', which took place in London on June 17 2011.
Arts and Humanities Research Council +3 more
core
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Transnational Corporations – Duty Bearers of Obligations to Respect Right to Food and Right to Environment as Human Rights: From Utopia to Reality? [PDF]
, 2023 Pavel Bureš, Monika A. Król
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Do Choice & Speed of Reforms Matter for Human Rights During Transition? [PDF]
, 2008 Conventional wisdom posits absence of systematic relationship between economic reforms and human rights. Taking the case of transition economies, Vadlamannati & Soysa (2008) shows significant positive relationship between economic reforms and various ...
Vadlamannati, Krishna Chaitanya
core +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Post-2015 WASH targets and indicators: a review from a Human Rights Perspective [PDF]
, 2013 Informe ...
Flores Baquero, Óscar +3 more
core +1 more source