Results 51 to 60 of about 1,593,200 (308)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Overcoming Barriers to People of Color in Union Leadership [PDF]
, 2005 [Excerpt] It has been 10 years since the report on full participation. In preparation for the 2005 AFL-CIO Convention, the AFL-CIO, under the direction of the Executive Council’s Civil and Human Rights Committee, initiated a study to consider what other ...
AFL-CIO
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Московский журнал международного права, 2018 . In the article they reveal the current practice of the courts of the Russian Federation, concerning the implementation of international treaty bodes legal positions in the way of interpretation of the legislation of the Russian Federation, generally ...
B. L. ZIMNENKO
doaj +1 more source
Revista Videre, 2020 In its Teitiota v. New Zeland’s landmark decision, The UN Human Rights Committee set out two fundamental principles of international law. It recognizes that the effects of climate change and natural disasters may give rise to violations of the right to ...
Michela Castiglione
doaj +1 more source
Introduction: Mental health and human rights: social policy and sociological perspectives [PDF]
, 2009 Recognition of the effects of social, economic, political and cultural conditions on mental health and the personal, social and economic costs of a growing global mental health crisis (WHO, 2001; EC, 2005) mean that mental health and well-being are a ...
Beresford +4 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Freedom of opinion and expression in the ICCPR Human Rights Committee’s General Observation No. 34
Anuario de Derechos Humanos, 2012 In 2011 the Human Rights Committee brought out General Comment No. 34 on the right to freedom of opinion and expression. This article explores the content of this document by first evaluating the way in which the Committee interprets the positive sphere ...
Simón Conforti
doaj +1 more source
Shareholder Engagement and Chevron’s Policy 520 on Human Rights: The Role Played by the United States Jesuit Conference’s “National Jesuit Committee on Investment Responsibility” [PDF]
, 2014 Purpose To demonstrate how the Society of Jesus (Jesuits) in the United States through the “National Jesuit Committee on Investment Responsibility” played a significant role as a socially conscious institutional and religious investor in influencing ...
Onuoha, Austin G. C. +2 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source