Results 81 to 90 of about 1,593,200 (308)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Take Action: 2008 and Beyond [PDF]
, 2007 The Organizing Committee for the 2008 Beijing Olympic Games issued the "Beijing Olympic Action Plan," which laid out guiding principles and a series of promises as part of Beijing's preparations to be host city.In 2003,Human Rights in China (HRIC ...
Carol Wang +2 more
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Sub-National Human Rights Institutions and Transgovernmental Networks [PDF]
, 2015 Transgovernmental networks have played a prominent role in the evolution and development of national human rights institutions (‘NHRIs’) by promoting cooperation, best practices, and engagement at the international level, and providing NHRIs with ...
Wolman, A.
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Access to an Effective Remedy in European Asylum Procedures [PDF]
, 2008 In this contribution the author tries to identify the meaning and content of the Community principles of effectiveness and effective judicial protection with regard to the right of access to an effective remedy in the context of the Common European ...
Reneman, A.M.
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
International legal means of protecting human rights and freedoms
Теорія і практика правознавства, 2019 The article deals with the application of international legal means of protection of human rights and freedoms in Ukraine. The content of the main acts of international law, which guarantee the ability to protect their rights and freedoms from illegal ...
Олександр Миколайович Похил
doaj +1 more source
The Dynamic Impact of Periodic Review on Women’s Rights [PDF]
, 2018 Human rights treaty bodies have been frequently criticized as useless and the regime’s self-reporting procedure widely viewed as a whitewash. Yet very little research explores what, if any, influence this periodic review process has on governments ...
Creamer, Cosette D., Simmons, Beth A.
core +2 more sources