Results 31 to 40 of about 38,485,025 (213)

Cellular tropism exhibited by human T lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) [PDF]

Retrovirology, 2011
Background HTLV-1 predominantly transforms CD4+T cells in vitro and induces leukemia and neurological disease in vivo, whereas HTLV-2 shows a preference for CD8+T cell transformation in vitro with limited in vivo pathology. To better understand cellular tropism of HTLV-1 and HTLV-2 early after in vivo infection we determined proviral load and gene ...
Green Patrick L, Doueiri Rami, Yin Han, Kannian Priya   +3 more
doaj   +2 more sources

Utilization of the CBP but not the p300 co-activator by human T-lymphotropic virus type-2 Tax for p53 inhibition [PDF]

Oncogene, 2004
We previously reported, both in transfected cells and in human T-cell leukemia virus type-2 subtype B infected cells, that the viral transactivator Tax-2B protein could inhibit p53 functions. We have now investigated the mechanism through which Tax-2B represses p53 using GFPTax-2B fusion proteins.
Laurent, Meertens, Cynthia, Pise-Masison, Nelly, Quere, John, Brady, Antoine, Gessain, Renaud, Mahieux   +5 more
openaire   +2 more sources

SHTLV-I/II seroprevalence in blood donors of Hospital Pablo Tobón Uribe Blood Bank during the period 2014-2015

Biomédica: revista del Instituto Nacional de Salud, 2018
Introduction: The human-T cell lymphotropic virus is a retrovirus with various types known so far. HTLV-I and HTLV-II are of clinically importance as they cause different diseases such as adult T-cell leukemia/lymphoma, tropical spastic paraparesis, and ...
Manuela Muñoz, Santiago Carvalho, Jorge Hernando Donado, Gloria Eugenia Barco, Sergio Jaramillo   +4 more
doaj   +1 more source

Plasma proteome analysis in HTLV-1-associated myelopathy/tropical spastic paraparesis [PDF]

, 2011
Background: Human T lymphotropic virus Type 1 (HTLV-1) causes a chronic inflammatory disease of the central nervous system known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM) which resembles chronic spinal forms of multiple ...
Stumpf, M. P. H. (Michael P. H.), Aviva Witkover, Bangham, Charles RM, Kirk, Paul, Taylor, Graham P, Kirk Paul DW, Lewin Alexandra M, Kirk, Paul DW, Bangham Charles RM, Bangham, C. R. M. (Charles R. M.), Taylor, G. P. (Graham P.), Lewin, Alexandra M, Courtney, A, Kirk, PDW, Richardson, Sylvia, Wait Robin, Witkover, A, Lewin, Alexandra M., Alan Courtney, Robin Wait, Graham P Taylor, Courtney Alan, Michael PH Stumpf, Charles RM Bangham, Witkover Aviva, Witkover, Aviva, Wait, R, Paul DW Kirk, Wait, Robin, Richardson, S, Taylor Graham P, Bangham, CRM, Courtney, Alan, Bangham, CR, Richardson Sylvia, Stumpf, MP, Sylvia Richardson, Stumpf, Michael PH, Kirk, PD, Stumpf, MPH, Taylor, GP, Stumpf Michael PH, Alexandra M Lewin, Lewin, AM   +43 more
core   +1 more source

Human T-lymphotropic virus types 1 and 2 are rare among intravenous drug users in Eastern Europe [PDF]

Infection, Genetics and Evolution, 2016
In Europe, human T-lymphotropic virus (HTLV) type 2 mainly occurs among intravenous drug users (IDUs) with prevalence up to 15% and HTLV-1 among general population with prevalence
Ene-Ly, Jõgeda, Radko, Avi, Merit, Pauskar, Eveli, Kallas, Tõnis, Karki, Don, Des Jarlais, Anneli, Uusküla, Irja, Lutsar, Kristi, Huik   +8 more
openaire   +2 more sources

The influence of human T lymphotropic virus type I infection on the outcome of cardiovascular surgery [PDF]

, 2000
Objective: Human T lymphotropic virus type I infects CD4+ T cells and affects cell-mediated immunity. Cardiopulmonary bypass transiently alters lymphocyte subsets, resulting in a reduction in CD4+ T cells and an increase in CD8+ T cells. We proposed that
Masuda, Hiroshi, Iguro, Yoshifumi, Watanabe, Shun-ichi, Hisatomi, Kouichi, Toda, Riichiro, Shimokawa, Shinji, Moriyama, Yukinori, Matsumoto, Hitoshi, Taira, Akira   +8 more
core   +1 more source

Human T-lymphotropic virus 1/2 infection among immigrants and refugees in Central Brazil, an emerging vulnerable population

Frontiers in Public Health, 2023
IntroductionMigratory flows play a significant role in the spread of human T-lymphotropic virus 1/2 (HTLV-1/2). In the last decade, a substantial migration of individuals occurred from Haiti and Venezuela to Brazil. However, data on the prevalence of HTLV-1/2 infection among these international migrants in Brazil are scarce.
Thaís Augusto Marinho, Larissa Silva Magalhães, Kamila Cardoso dos Santos, Thaynara Lorrane Silva Martins, Grazielle Rosa da Costa e Silva, Ágabo Macedo da Costa e Silva, Megmar Aparecida dos Santos Carneiro, Karlla Antonieta Amorim Caetano, Sheila Araújo Teles, Regina Maria Bringel Martins   +9 more
openaire   +3 more sources

A Machine Learning Approach for MicroRNA Precursor Prediction in Retro-transcribing Virus Genomes

Journal of Integrative Bioinformatics, 2016
Identification of microRNA (miRNA) precursors has seen increased efforts in recent years. The difficulty in experimental detection of pre-miRNAs increased the usage of computational approaches. Most of these approaches rely on machine learning especially
Demirci Müşerref Duygu Saçar, Toprak Mustafa, Allmer Jens   +2 more
doaj   +1 more source

Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects

Viruses, 2016
Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of ...
Benjamin Usadi, Roberta Bruhn, Jue Lin, Tzong-Hae Lee, Elizabeth Blackburn, Edward L. Murphy   +5 more
doaj   +1 more source

Biochemical Characterization, Specificity and Inhibition Studies of HTLV-1, HTLV-2, and HTLV-3 Proteases

Life, 2021
The human T-lymphotropic viruses (HTLVs) are causative agents of severe diseases including adult T-cell leukemia. Similar to human immunodeficiency viruses (HIVs), the viral protease (PR) plays a crucial role in the viral life-cycle via the processing of
Norbert Kassay, János András Mótyán, Krisztina Matúz, Mária Golda, József Tőzsér   +4 more
doaj   +1 more source