Results 61 to 70 of about 9,000,670 (290)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish
Cell Regeneration, 2016 Background: We are using genetics to identify genes specifically involved in hearing regeneration. In a large-scale genetic screening, we identified mgat5a, a gene in the N-glycosylation biosynthesis pathway whose activity negatively impacts hair cell ...
Wuhong Pei +7 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Studia Romanica Posnaniensia, 2019 In this article the author analyzes the evolution of the role of the translator in a world dominated by new technologies and the influence of these on the training of future translators. She focuses primarily on machine translation and post-editing. The
Teresa Tomaszkiewicz
doaj
Frontiers in PediatricsIntroductionChildren with developmental coordination disorder (DCD) have difficulties with learning and performing physical tasks. It is well known that task-specific practice is effective in improving motor skills.
Ellana Welsby +6 more
doaj +1 more source
مجلة الدراسات الاجتماعية, 2013 It is important that girls have access to education as not only does it benefit girls' , but also the community in which they live. Education helps girls to develop skills that allow them to influence improving changes in key areas and to approve some of
Eman Alshargabi
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Seeding statistical machine translation with translation memory output through tree-based structural alignment [PDF]
, 2010 With the steadily increasing demand for high-quality translation, the localisation industry is constantly searching for technologies that would increase translator throughput, with the current focus on the use of high-quality Statistical Machine ...
Zhechev, Ventsislav, van Genabith, Josef
core +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
AI-LinguisticaThe purpose of this chapter is to examine the neural machine translation of modal particles and to compare it to human translation. The quantitatively-oriented study focuses on Italian lexical translation equivalents of German eben and einfach.
Franz Meier
doaj +1 more source