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Humanized mice for immune system investigation: progress, promise and challenges
Nature Reviews Immunology, 2012 Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from the development of \u27humanized\u27 mouse strains that are based on severely immunodeficient mice with mutations
Leonard D Shultz +2 more
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THE ASSAY OF HUMAN THYROCALCITONIN IN MICE
Journal of Endocrinology, 1967SUMMARY A mouse assay for thyrocalcitonin using either intravenous or intraperitoneal injections is described. Responses to porcine thyroid extracts were similar to those in rats. Extracts of human thyroid glands obtained at autopsy or surgical operation caused hypocalcaemia in the mouse.
H C, Laljee, R N, Smith, K J, Dorrington
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Humanized Mice for Human Retrovirus Infection
2008Inbred mice with specific genetic defects have greatly facilitated the analysis of complex biological events. Several humanized mouse models using the C.B.-17 scid/scid mouse (referred to as the SCID mouse) have been created from two transplantation protocols, and these mice have been utilized for the investigation of human immunodeficiency virus type ...
Y, Koyanagi +3 more
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Production of Human or Humanized Antibodies in Mice
2012Mice are widely available laboratory animals that can easily be used for the production of antibodies against a broad range of antigens, using well-defined immunization protocols. Such an approach allows optimal in vivo affinity maturation of the humoral response.
Laffleur, Brice +3 more
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Circadian Photoreception in Humans and Mice
Molecular Interventions, 2002Circadian rhythms are the endogenous oscillations, occurring with a periodicity of approximately twenty-four hours, in the biochemical and behavioral functions of organisms. In mammals, the phase and period of the rhythm are synchronized to the daily light-dark cycle by light input through the eye.
Ibrahim Halil, Kavakli, Aziz, Sancar
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Embryonic hematopoiesis in mice and humans
Acta Paediatrica, 2002Aim: The aim of this report is to review briefly the ontogeny of hematopoiesis in mice and humans and to discuss recent evidence for an intraembryonic source of hematopoietic stem cells. Methods: The hematopoiesis overview summarizes information present in the PubMed online database and from experiments conducted in our laboratories.
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Humanized mice in infectious diseases
Comparative Immunology, Microbiology and Infectious Diseases, 2016The pathogenesis of infectious agents with human tropism can only be properly studied in an in vivo model featuring human cells or tissue. Humanized mice represent a small animal model featuring human cells or tissue that can be infected by human-specific viruses, bacteria, and parasites and also providing a functional human immune system.
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The orphan granzymes of humans and mice
Current Opinion in Immunology, 2003The granzyme/perforin pathway is a central pathway for lymphocyte-mediated killing in both the innate and adaptive immune systems. This pathway is important in a variety of host defenses, including viral clearance and tumor cell killing, and its dysregulation results in several human and rodent diseases.
William J, Grossman +5 more
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VH replacement in mice and humans
Trends in Immunology, 2007Heavy chain variable segment (V(H)) replacement refers to recombination activating gene (RAG) product-mediated secondary recombination between a previously rearranged V(H) gene and an upstream unrearranged V(H) gene. V(H) replacement was first observed in mouse pre-B cell lines and later demonstrated in knock-in mouse models carrying immunoglobulin ...
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Chimeric mice with humanized liver
Toxicology, 2008Recently, chimeric mice with humanized liver were established by transplanting human hepatocytes into an urokinase-type plasminogen activator(+/+)/severe combined immunodeficient transgenic mouse line. The replacement with human hepatocytes is more than 80-90% and is higher than any other chimeric mouse reported previously.
Miki, Katoh +3 more
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