Results 161 to 170 of about 68,397 (297)

A comprehensive analysis of humanized mouse models for the study of cancer immunotherapies. [PDF]

Front Immunol
De La Rochere P, Loumagne L, Rathaux M, Dubois M, Denizeau J, Nemati F, Viel S, Rocha D, Slavnic T, Thatte J, Li HQ, Ouyang X, Sedlik C, Decaudin D, Azar G, Sidhu S, Piaggio E.   +16 more
europepmc   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery. [PDF]

Proc Natl Acad Sci U S A
Davey SD, Forde-Thomas JE, Hulme BJ, Lees K, Costain AH, Evans M, Rinaldi G, Frame L, Stojanovski L, Simeons FRC, Tavendale A, MacLeod AK, Pichon R, Lee YH, Polak O, Chalmers IW, Dankwa B, Odhiambo BK, Guimaraes VH, Hegarty M, Swain MT, Aubrey W, Caldwell N, MacDonald AS, Gilbert IH, Baragaña B, Read KD, Hoffmann KF.   +27 more
europepmc   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Long-acting IL-7 restores T-cell reconstitution in a humanized mouse model of lymphopenia. [PDF]

J Allergy Clin Immunol
Pérez-Díez A, Liu X, Bennett A, Barrios M, Anderson M, Wolfarth AA, Choi D, Lisco A, Sereti I.   +8 more
europepmc   +1 more source

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

TNF-α blockade mitigates immune checkpoint-related nephritis in a humanized mouse model. [PDF]

JCI Insight
Cuenca Narvaez VD, Nava Chavez C, Al Refai O, Jacobs JE, Gutierrez LE, Zhang S, Li X, Hirdler JB, Romero MF, Herrmann J, Li X, Dong H, Eirin A, Herrmann SM.   +13 more
europepmc   +1 more source

The evolving role of regulatory T cells in Sjögren's disease pathogenesis and the promise of Treg‐based therapies: A comprehensive review

Rheumatology &Autoimmunity, EarlyView.
Graphical Abstract The evolving role of regulatory T cells in primary Sjögren's disease pathogenesis and the promise of Treg‐based therapies. Abstract Sjögren's disease (SjD) is a chronic systemic autoimmune disorder characterised by exocrine gland dysfunction and diverse systemic manifestations.
Gagan Urs, Bharath Raj Srinivasan, Himabindu Jayaprakash Narayan, Mirunalini Gobinath, Lekitha Manjunath, Mahabaleshwar Mamadapur   +5 more
wiley   +1 more source

Immuno-radiotherapy enhances tumor control and induces abscopal responses in a humanized mouse model. [PDF]

Front Immunol
Cogels MM, Serra M, Duvillier H, Garaud S, Verset L, Venet D, Iliadi C, de Bakker T, Buisseret L, Rouas R, Sotiriou C, Rothé F, de Caluwé A, Van Gestel D, Penninckx S.   +14 more
europepmc   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, EarlyView.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source