Results 81 to 90 of about 15,911 (332)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Journal of Air Pollution and HealthIntroduction: Indoor air pollution poses significant health risks, given the substantial time individuals spend indoors. Cool-mist humidifiers have been proposed as a potential intervention for enhancing indoor air quality by influencing pollutant ...
Maryam Malekbala +5 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Continuous hydroponic wheat production using a recirculating system [PDF]
Continuous crop production, where plants of various ages are growing simultaneously in a single recirculating nutrient solution, is a possible alternative to batch production in a Controlled Ecological Life Support System. A study was conducted at John F.
Hinkle, C. R. +3 more
core +1 more source
In-situ U-value-measurements of wood frame roofs: analysis of deviations between measured and design performance [PDF]
, 2013 The hygrothermal performance of various lightweight sloped roof designs was monitored in the KULeuven VLIET testbuilding for 2 years (Janssens et al. 1998). One of the aims of the investigation was to evaluate whether the design U-value of 0.18 W/m²K was
Janssens, Arnold
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
MICROBIAL COLONIZATION PROFILE OF RESPIRATORY DEVICES
National Journal of Medical Research, 2016 Background: The respiratory care equipment’s which include nebulizers, humidifiers, and ventilators may have been identified as the potential vehicle which may cause major nosocomial infections if they are colonized by different bacteria. This study was
Krutika Nitin, Umesh Santlal Hassani
doaj
BMC Infectious Diseases, 2013 Background Low absolute humidity (AH) has been associated with increased influenza virus survival and transmissibility and the onset of seasonal influenza outbreaks.
Koep Tyler H +8 more
doaj +1 more source