Results 71 to 80 of about 1,351,596 (242)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Balloon-Shaped Optical Fiber Humidity Sensor Based on PVA Coating for Respiratory Monitoring

Photonics
A polyvinyl alcohol (PVA)-coated optical fiber humidity sensor for respiratory monitoring is proposed. The humidity sensor forms a fiber Mach–Zehnder interferometer (MZI) by bending the single-mode fiber (SMF) coated with PVA. The refractive index of PVA
Qingfeng Shi, Yunkun Cui, Wenyan Xu, Yu Zhang, Feng Peng   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Nonporous Inorganic Nanoparticle-Based Humidity Sensor: Evaluation of Humidity Hysteresis and Response Time

, 2020
Fast-response humidity sensors using nanomaterials are attractive and have been intensively studied. Among the various nanomaterials, nonporous inorganic nanoparticles are suitable for use in humidity sensitive films for sensors.
Harutaka Mekaru, Shinya Kano
core   +1 more source

Humidity Responsive Photonic Sensor based on a Carboxymethyl Cellulose Mechanical Actuator [PDF]

, 2017
We describe an intuitive and simple method for exploiting humidity-driven volume changes in carboxymethyl cellulose (CMC) to fabricate a humidity responsive actuator on a glass fiber substrate.
Zeeshan, Ahmed, Matthew, Hartings, Claire, Neice, Kevin O., Douglass   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Remote assessment of cultural heritage environments with wireless sensor array networks [PDF]

, 2014
The logistics and cost of environmental monitoring can represent challenges for heritage managers, partly because of the sheer number of environmental parameters to consider.
Agbota, H, John E. Mitchell, Agbota, H., Odlyha, M, Mitchell, JE, Marianne Odlyha, Odlyha, Marianne, Strlič, M, Henoc Agbota, John Mitchell, Mitchell, J., Strlič, M., Matija Strlič   +12 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A biologically-inspired approach to designing wireless sensor networks [PDF]

, 2005
In this paper, we contend that there are significant advantages in treating some classes of sensor networks as biological-like systems-- both in structural design characteristics and in operational processes.
Haddadi, H., Sacks, L., Shum, V., Britton, M.   +3 more
core   +1 more source