Results 91 to 100 of about 37,460 (168)

Reduced Palmitoylation of SQSTM1/p62 in Huntington Disease Is Associated With Impaired Autophagy

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Sequestosome 1 (SQSTM1)/p62 is a receptor for autophagy required to deliver damaged organelles and aggregated proteins to the lysosome for degradation. SQSTM1 undergoes palmitoylation, the reversible addition of the saturated fatty acid palmitate to cysteines.
F. Abrar, M. C. Davies, Y. Alshehabi, A. Kumar, A. Dang, Y. T. N. Nguyen, J. Collins, N. S. Caron, J. S. Choudhary, S. S. Sanders, M. O. Collins, M. R. Hayden, D. D. O. Martin   +12 more
wiley   +1 more source

Huntington\u27s Disease--A Review [PDF]

, 2016
Huntington’s disease is degenerative and effects both cognitive and motor functioning, beginning in the 20s and continuing a decline for about two decades until death.
Dunn, Christen
core   +1 more source

The mRNA expression of SETD2 in human breast cancer: Correlation with clinico-athological parameters [PDF]

, 2009
BACKGROUND: SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes.
AP Cuthbert, AP Wolffe, BD Strahl, BM Turner, C Prives, DS Goodsell, JW Edmunds, K Mokbel, LA Passani, M Li, P Xie, PW Faber, RF Newbold, S Rega, T Roberts, VA Spencer, W Al Sarakbi, W Sasi, WG Jiang, WG Jiang, WG Jiang, WG Jiang, XJ Sun   +22 more
core   +4 more sources

Cortical and Striatal Circuits in Huntington's Disease

, 2020
Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically manifests in midlife with motor, cognitive, and/or psychiatric symptoms.
Blumenstock, S., Dudanova, I.
core   +1 more source

Huntingtin and mitosis

, 2012
La maladie de Huntington (MH) est une maladie neurodégénérative héréditaire autosomique dominante. Elle résulte d’une expansion anormale de glutamines (polyQ) dans la partie N-terminale de la protéine huntingtine (HTT ; codé par HTT). La MH est caractérisée par la dysfonction et la mort de cellules neuronales dans le cerveau, entraînant l’apparition de
openaire   +2 more sources

Multiple discrete soluble aggregates influence polyglutamine toxicity in a Huntington\u27s disease model system [PDF]

, 2016
Huntington’s disease (HD) results from expansions of polyglutamine stretches (polyQ) in the huntingtin protein (Htt) that promote protein aggregation, neurodegeneration, and death.
Denis, Clyde L., Wang, Xin, Xi, Wen
core   +1 more source

Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis [PDF]

, 2013
Brown, Euan R., Idris, Mohammed M, Thorndyke, Michael C   +2 more
core   +1 more source

Is huntingtin a modulator of VDAC?

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012
Karachitos A, Stobienia O, Jordan J, DE PINTO, Vito Nicola, Kmita H.   +4 more
openaire   +3 more sources

The proteostasis network and its decline in ageing

, 2019
Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Hartl, F., Hipp, M., Kasturi, P.
core   +1 more source

Localization and function of the Drosophila huntingtin protein [PDF]

, 2007
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2007."September 3, 2007."Includes bibliographical references (p. 34-40).Huntington's Disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expansion of a ...
Mediatore, James D
core