Results 141 to 150 of about 44,176 (282)

Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease

, 2020
Filipe B. Rodrigues, Lauren M. Byrne, Rosanna Tortelli, Eileanoir B. Johnson, P. A. Wijeratne, Marzena Arridge, Enrico De Vita, Naghmeh Ghazaleh, Richard Houghton, Hannah Furby, Daniel C. Alexander, Sarah J. Tabrizi, Scott Schobel, Rachael I. Scahill, Amanda Heslegrave, Henrik Zetterberg, Edward J. Wild   +16 more
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The Cellular and Subcellular Localization of Huntingtin-Associated Protein 1 (HAP1): Comparison with Huntingtin in Rat and Human [PDF]

, 1998
Claire‐Anne Gutekunst, Shihua Li, Hong Yi, Robert J. Ferrante, Xiao‐Jiang Li, Steven M. Hersch   +5 more
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Cdk5 protects huntingtin

The Journal of Cell Biology, 2005
![Graphic][1] Cdk5 (red) phosphorylates htt (green) and protects it from caspases.A cyclin-dependent kinase protects neurons from toxic fragments of huntingtin (htt), according to Luo et al.
openaire   +2 more sources

Huntingtin [PDF]

Science-Business eXchange, 2008
openaire   +2 more sources

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage [PDF]

, 2017
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD)
Albin, Roger, Augood, Sarah J., Bates, Gillian P., Becanovic, Kristina, Cha, Jang-Ho J., Delorenzi, Mauro, Dunnett, Stephen B., Faull, Richard L.M., Ferrante, Robert J., Goldstein, Darlene R., Hannan, Anthony J., Hayden, Michael R., Hodges, Angela, Jones, Lesley, Kooperberg, Charles, Kuhn, Alexandre, Leavitt, Blair R., Luthi-Carter, Ruth, Olson, James M., Pouladi, Mahmoud A., Sathasivam, Kirupa, Sengstag, Thierry, Shelbourne, Peggy, Strand, Andrew D.   +23 more
core  

Mutant Huntingtin in Glial Cells Exacerbates Neurological Symptoms of Huntington Disease Mice [PDF]

, 2010
Jennifer W. Bradford, Ji‐Yeon Shin, Meredith Roberts, Chuan-En Wang, Guoqing Sheng, Shihua Li, Xiao‐Jiang Li   +6 more
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Preserved VPS13A distribution and expression in Huntington’s disease: divergent mechanisms of action for similar movement disorders?

Frontiers in Neuroscience
VPS13A disease and Huntington’s disease (HD) are two basal ganglia disorders that may be difficult to distinguish clinically because they have similar symptoms, neuropathological features, and cellular dysfunctions with selective degeneration of the ...
Esther García-García, Esther García-García, Esther García-García, Maria Carreras-Caballé, Maria Carreras-Caballé, Albert Coll-Manzano, Alba Ramón-Lainez, Alba Ramón-Lainez, Alba Ramón-Lainez, Gisela Besa-Selva, Gisela Besa-Selva, Gisela Besa-Selva, Esther Pérez-Navarro, Esther Pérez-Navarro, Esther Pérez-Navarro, Cristina Malagelada, Cristina Malagelada, Cristina Malagelada, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Mercè Masana, Mercè Masana, Mercè Masana, Manuel J. Rodríguez, Manuel J. Rodríguez, Manuel J. Rodríguez   +27 more
doaj   +1 more source

Additional file 5 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin

, 2020
Manuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek   +8 more
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Tadpole-like conformations of huntingtin exon 1 with expanded polyglutamine engenders novel interactions in cells [PDF]

, 2017
Estella A. Newcombe, Kiersten M. Ruff, Ashish Sethi, Angelique R. Ormsby, Yasmin M. Ramdzan, Archa H. Fox, Anthony W. Purcell, Paul R. Gooley, Rohit V. Pappu, Danny M. Hatters   +9 more
openalex   +1 more source

Huntingtin (HTT) [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources