Results 161 to 170 of about 49,474 (299)

Alterations of NMDAR Subunits in the Cerebrospinal Fluid Across Neurodegenerative and Immunological Disorders

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
NMDA receptors are essential for brain communication and are involved in various brain diseases. This study shows, for the first time, that full‐length NMDA receptor subunits are present in cerebrospinal fluid (CSF), a fluid surrounding the brain. By analyzing samples from healthy people and patients with conditions like encephalitis, Huntington's ...
Sergio Escamilla, Rocío Pérez‐González, Carmen Márquez‐Marco, Elena Camporesi, Gunnar Brinkmalm, Alessandro Padovani, Andrea Pilotto, Chiara Tolassi, Davide Arici, Irene Volonghi, Henrik Zetterberg, Kaj Blennow, Jesús Pérez‐Pérez, Jaime Kulisevsky, Inmaculada Cuchillo‐Ibáñez, Javier Sáez‐Valero   +15 more
wiley   +1 more source

Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins

Scientific Reports, 2019
There is still no successful strategy to treat Huntington’s disease, an inherited autosomal disorder associated with the aggregation of mutated forms of the huntingtin protein containing polyglutamine tracts with more than 36 repeats. Recent experimental
S. Bonfanti, M. C. Lionetti, M. R. Fumagalli, Venkat R. Chirasani, G. Tiana, N. Dokholyan, S. Zapperi, C. L. La Porta   +7 more
semanticscholar   +1 more source

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. [PDF]

, 1995
C A Gutekunst, Allan I. Levey, C J Heilman, William L. Whaley, Hong Yi, N. R. Nash, Howard D. Rees, John J. Madden, Steven M. Hersch   +8 more
openalex   +1 more source

Detection of ubiquitinated huntingtin species in intracellular aggregates

Frontiers in Molecular Neuroscience, 2015
Protein conformation diseases, including polyglutamine diseases, result from the accumulation and aggregation of misfolded proteins. Huntington’s disease is one of nine diseases caused by an expanded polyglutamine repeat within the affected protein and ...
Katrin eJuenemann, Anne eWiemhoefer, Eric eReits   +2 more
doaj   +1 more source

N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance We have discovered a molecule derived from DNA-damage repair that can correct the lack of phosphorylation of mutant huntingtin, the cause of Huntington’s disease (HD).
L. Bowie, Tamara Maiuri, M. Alpaugh, Michelle Gabriel, N. Arbez, D. Galleguillos, C. L. Hung, Shreya A. Patel, Jianrun Xia, Nicholas T. Hertz, C. Ross, D. Litchfield, S. Sipione, R. Truant   +13 more
semanticscholar   +1 more source

Avoiding errors in the diagnosis of (CAG)n expansion in the huntingtin gene. [PDF]

, 1997
Carsten Holzmann, Ana Maria Menezes Saecker, Jörg T. Epplen, Olaf Rieß   +3 more
openalex   +1 more source

SH3GL3 Associates with the Huntingtin Exon 1 Protein and Promotes the Formation of Polygln-Containing Protein Aggregates [PDF]

, 1998
Annie Sittler, Stephanie Wälter, Niels Wedemeyer, Renate Hasenbank, Eberhard Scherzinger, Holger Eickhoff, Gillian P. Bates, Hans Lehrach, Erich E. Wanker   +8 more
openalex   +1 more source

The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

BMC Neuroscience, 2002
Background Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine disorders also implies a role for the protein's unknown inherent function ...
Gusella James F, Takano Hiroki
doaj   +1 more source

α-Synuclein overexpression promotes aggregation of mutant huntingtin [PDF]

, 2000
Robert A. FURLONG, Yolanda NARAIN, Julia RANKIN, Andreas Wyttenbach, David C. Rubinsztein   +4 more
openalex   +2 more sources

Localization and function of the Drosophila huntingtin protein [PDF]

, 2007
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2007."September 3, 2007."Includes bibliographical references (p. 34-40).Huntington's Disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expansion of a ...
Mediatore, James D
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