Results 191 to 200 of about 49,474 (299)

Huntingtin Lowering Strategies for Disease Modification in Huntington’s Disease

Neuron, 2019
S. Tabrizi, R. Ghosh, B. Leavitt
semanticscholar   +1 more source

CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain

, 1995
Neil Aronin, Kathryn Chase, Christine Young, Ellen Sapp, Cordula Schwarz, N. K. Matta, Ruth Kornreich, Bernhard Lanwehrmeyer, Edward J. Bird, M. Flint Beal, Jean-Paul G. Vonsattel, Thomas J. Smith, Robert E. Carraway, Frederick M. Boyce, Anne B. Young, John B. Penney, Marian DiFiglia   +16 more
openalex   +1 more source

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Nature, 2004
M. Arrasate, S. Mitra, E. Schweitzer, M. Segal, S. Finkbeiner   +4 more
semanticscholar   +1 more source

Huntingtin Interacting Protein 1 Induces Apoptosis via a Novel Caspase-dependent Death Effector Domain [PDF]

, 2000
Abigail S. Hackam, Ayman S. Yassa, Roshni R. Singaraja, Martina Metzler, Claire-Anne Gutekunst, Lu Gan, Simon C. Warby, Cheryl L. Wellington, John P. Vaillancourt, Nansheng Chen, François G. Gervais, Lynn A. Raymond, Donald W. Nicholson, Michael R. Hayden   +13 more
openalex   +1 more source

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis [PDF]

, 2001
Sébastien Holbert, Isabelle Denghien, Tamara Kiechle, Adam Rosenblatt, Cheryl L. Wellington, Michael R. Hayden, Russell L. Margolis, Christopher A. Ross, J Dausset, Robert J. Ferrante, Christian Néri   +10 more
openalex   +2 more sources

Mutant Huntingtin Expression in Clonal Striatal Cells: Dissociation of Inclusion Formation and Neuronal Survival by Caspase Inhibition

, 1999
Manho Kim, H-S Lee, Genevieve Laforet, Charmian McIntyre, Eileen J. Martin, Patrick Chang, Tae Wan Kim, Michael Williams, P. Hemachandra Reddy, Dan Tagle, Frederick M. Boyce, Lisa Won, Alfred Heller, Neil Aronin, Marian DiFiglia   +14 more
openalex   +1 more source

Nuclear Targeting of Mutant Huntingtin Increases Toxicity

, 1999
Matthew F. Peters, Frederick C. Nucifora, Jonathan Kushi, Holly C. Seaman, Jillian K. Cooper, W. Joseph Herring, Valina L. Dawson, Ted M. Dawson, Christopher A. Ross   +8 more
openalex   +1 more source

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release [PDF]

, 2001
Nihar Ranjan Jana
openalex   +1 more source

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation

Molecules and Cells, 2018
Thomas R. Peskett, F. Rau, J. O’Driscoll, R. Patani, Alan R. Lowe, H. Saibil   +5 more
semanticscholar   +1 more source

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease [PDF]

, 2001
Annie Sittler
openalex   +1 more source