Results 211 to 220 of about 25,505 (239)
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New England Journal of Medicine, 2012
Huntington's disease was the first disease whose causative gene (HTT) was mapped to a chromosome, and yet almost 30 years later, rational treatments do not exist. A recent study using a mouse model supports a strategy to knock down HTT RNA.
Neil, Aronin, Melissa, Moore
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Huntington's disease was the first disease whose causative gene (HTT) was mapped to a chromosome, and yet almost 30 years later, rational treatments do not exist. A recent study using a mouse model supports a strategy to knock down HTT RNA.
Neil, Aronin, Melissa, Moore
openaire +2 more sources
Calretinin interacts with huntingtin and reduces mutant huntingtin‐caused cytotoxicity
Journal of Neurochemistry, 2012AbstractHuntington's disease (HD) is a devastating neurodegenerative disorder caused by an expansion of CAG trinucleotide repeats encoding for polyglutamine (polyQ) in the huntingtin (Htt) gene. Despite considerable effort, the mechanisms underlying the toxicity of the mutated Htt protein remains largely uncertain. To identify novel therapeutic targets,
Gaofeng, Dong +9 more
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Characterization of neuron-specific huntingtin aggregates in human huntingtin knock-in mice
Neuroscience Research, 2007Huntington's disease (HD) is caused by a mutation causing expanded polyglutamine tracts in the N-terminal fragment of huntingtin. A pathological hallmark of HD is the formation of aggregates in the striatal neurons. Here we report that ageing human huntingtin knock-in mice expressing mutant human huntingtin contained neuronal huntingtin aggregates, as ...
Hirohide, Sawada +8 more
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Science's STKE, 2002
Huntington's disease (HD) is characterized by progressive brain neurodegeneration, often leading to dementia. A mutation in the huntingtin protein and nuclear accumulation of the mutant are associated with the pathology of HD, but it is not yet clear how the mutant protein induces the death of neurons.
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Huntington's disease (HD) is characterized by progressive brain neurodegeneration, often leading to dementia. A mutation in the huntingtin protein and nuclear accumulation of the mutant are associated with the pathology of HD, but it is not yet clear how the mutant protein induces the death of neurons.
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Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease
Autophagy, 2021Sandra Franco-Iborra +2 more
exaly
Emerging Therapies for Huntington’s Disease – Focus on N-Terminal Huntingtin and Huntingtin Exon 1
Biologics: Targets and Therapy, 2022M Leontien Van Der Bent +2 more
exaly