Results 191 to 200 of about 40,748 (225)

Dysregulation of store-operated calcium entry in fibroblast lines from adult and juvenile-onset Huntington's disease patients. [PDF]

Pharmacol Rep
Egbuwalo SO, Latoszek E, Hansíková H, Hansíková H, Klempíř J, Mühlbäck A, Landwehrmeyer GB, Kuźnicki J, Czeredys M.   +8 more
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Aberrant medial ganglionic eminence (MGE) GABAergic neurogenesis contributes to Huntington's disease pathogenesis. [PDF]

Neurobiol Dis
Molero AE, Devakanmalai GS, Altun YM, Jover-Mengual T, Zhang J, Khan N, Mehler MF.   +6 more
europepmc   +1 more source

Chimeric degraders in neurodegenerative diseases: Challenges and future directions. [PDF]

J Transl Int Med
Zheng H, Cui K, Mao J, Wan Y, Zheng J.
europepmc   +1 more source

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Hunting Down Huntingtin

New England Journal of Medicine, 2012
Huntington's disease was the first disease whose causative gene (HTT) was mapped to a chromosome, and yet almost 30 years later, rational treatments do not exist. A recent study using a mouse model supports a strategy to knock down HTT RNA.
Neil, Aronin, Melissa, Moore
openaire   +2 more sources

Calretinin interacts with huntingtin and reduces mutant huntingtin‐caused cytotoxicity

Journal of Neurochemistry, 2012
AbstractHuntington's disease (HD) is a devastating neurodegenerative disorder caused by an expansion of CAG trinucleotide repeats encoding for polyglutamine (polyQ) in the huntingtin (Htt) gene. Despite considerable effort, the mechanisms underlying the toxicity of the mutated Htt protein remains largely uncertain. To identify novel therapeutic targets,
Gaofeng, Dong, Kylie, Gross, Fangfang, Qiao, Justine, Ferguson, Eduardo A, Callegari, Khosrow, Rezvani, Dong, Zhang, Christian J, Gloeckner, Marius, Ueffing, Hongmin, Wang   +9 more
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The Huntingtin Transport Complex

Biochemistry
A dynamic network of scaffolding molecules, adaptor proteins, and motor proteins work together to orchestrate the movement of proteins, mRNA, and vesicular cargoes. Defects in intracellular transport can often lead to neurodegeneration. Huntingtin (HTT) is a ubiquitously expressed scaffolding protein with a multitude of cellular roles, including ...
Emily N. P. Prowse, Brooke A. Turkalj, Lale Gursu, Adam G. Hendricks   +3 more
openaire   +2 more sources