Results 201 to 210 of about 40,748 (225)
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Science's STKE, 2002
Huntington's disease (HD) is characterized by progressive brain neurodegeneration, often leading to dementia. A mutation in the huntingtin protein and nuclear accumulation of the mutant are associated with the pathology of HD, but it is not yet clear how the mutant protein induces the death of neurons.
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Huntington's disease (HD) is characterized by progressive brain neurodegeneration, often leading to dementia. A mutation in the huntingtin protein and nuclear accumulation of the mutant are associated with the pathology of HD, but it is not yet clear how the mutant protein induces the death of neurons.
openaire +2 more sources
Characterization of neuron-specific huntingtin aggregates in human huntingtin knock-in mice
Neuroscience Research, 2007Huntington's disease (HD) is caused by a mutation causing expanded polyglutamine tracts in the N-terminal fragment of huntingtin. A pathological hallmark of HD is the formation of aggregates in the striatal neurons. Here we report that ageing human huntingtin knock-in mice expressing mutant human huntingtin contained neuronal huntingtin aggregates, as ...
Hirohide, Sawada +8 more
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Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease
Autophagy, 2021Sandra Franco-Iborra +2 more
exaly
Emerging Therapies for Huntington’s Disease – Focus on N-Terminal Huntingtin and Huntingtin Exon 1
Biologics: Targets and Therapy, 2022Astrid Valles
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Loss of normal huntingtin function: new developments in Huntington's disease research
Trends in Neurosciences, 2001Ferdinando Squitieri +2 more
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