Results 81 to 90 of about 28,868 (258)
Mitochondrial dysfunction: Related diseases, influencing factors, and detection
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li +9 more
wiley +1 more source
Molecular Brain, 2009 Background Huntington's disease (HD) is an inherited neurogenerative disease caused by an abnormal expansion of glutamine repeats in the huntingtin protein.
Pineda Jose R +5 more
doaj +1 more source
Acta Neuropathologica Communications, 2020 Prominent features of HD neuropathology are the intranuclear and cytoplasmic inclusions of huntingtin and striatal and cortical neuronal cell death.
Ting-Ting Huang +6 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.ABSTRACT Background Thermoregulation is critical for preventing hyperthermia during physical activity. In Huntington's disease (HD), research on possible thermoregulatory alterations has received little attention. Objectives We aimed to investigate and compare skin temperature differences before and after exercise between HD patients and healthy ...
Lucía Simón‐Vicente +7 more
wiley +1 more source
The Hsp90β Isoform: An Attractive Target for Drug Development
Medicinal Research Reviews, EarlyView.ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury +2 more
wiley +1 more source
Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance [PDF]
The FASEB Journal, 2017 ABSTRACTHuntington disease (HD) is a progressive neurodegenerative disease that initially affects the striatum leading to changes in behavior and loss of motor coordination. It is caused by an expansion in the polyglutamine repeat at the N-terminus of huntingtin (HTT) that leads to aggregation of mutant HTT.
Martin, D.D.O. +4 more
openaire +4 more sources
Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
Molecular Neurodegeneration, 2011 Background Huntington's disease is caused by aggregation of mutant huntingtin (mHtt) protein containing more than a 36 polyQ repeat. Upregulation of macroautophagy was suggested as a neuroprotective strategy to degrade mutant huntingtin.
Ouyang Xiaosen +3 more
doaj +1 more source
Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
Science Translational Medicine, 2018 Mutant huntingtin suppression with antisense oligonucleotides reverses cognitive impairments in a mouse model of Huntington’s disease. Rescuing cognition in Huntington’s disease Huntington’s disease (HD) is a neurodegenerative disorder caused by mutation
Amber L. Southwell +18 more
semanticscholar +1 more source
Brain Pathology, EarlyView.Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li +7 more
wiley +1 more source
Linking Huntingtin to motility
The Journal of Cell Biology, 2006 On page 605, Pal et al. report that Huntingtin (Htt) and its associated protein HAP40 are part of the machinery used by Rab5 to control switching between microtubules and actin filaments. The data may explain why vesicle motility is disrupted in Htt mutant cells. Figure 1 Vesicular Rab5 (green) colocalizes with Huntingtin (red).
openaire +3 more sources