Results 101 to 110 of about 19,163 (188)

Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. [PDF]

Cell Syst, 2022
Greco TM, Secker C, Ramos ES, Federspiel JD, Liu JP, Perez AM, Al-Ramahi I, Cantle JP, Carroll JB, Botas J, Zeitlin SO, Wanker EE, Cristea IM.   +12 more
europepmc   +1 more source

Selective observation of semi-rigid non-core residues in dynamically complex mutant huntingtin protein fibrils. [PDF]

J Struct Biol X, 2022
Matlahov I, Boatz JC, van der Wel PCA.
europepmc   +1 more source

Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington's disease models. [PDF]

Cell Biosci, 2022
Latoszek E, Wiweger M, Ludwiczak J, Dunin-Horkawicz S, Kuznicki J, Czeredys M.   +5 more
europepmc   +1 more source

Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide. [PDF]

Proc Natl Acad Sci U S A, 2022
Song H, Wang C, Zhu C, Wang Z, Yang H, Wu P, Cui X, Botas J, Dang Y, Ding Y, Fei Y, Lu B.   +11 more
europepmc   +1 more source

N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate. [PDF]

J Biol Chem, 2021
Gottlieb L, Guo L, Shorter J, Marmorstein R.   +3 more
europepmc   +1 more source

Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease. [PDF]

J Huntingtons Dis, 2022
Podvin S, Rosenthal SB, Poon W, Wei E, Fisch KM, Hook V.   +5 more
europepmc   +1 more source

Quantifying Huntingtin Protein in Human Cerebrospinal Fluid Using a Novel Polyglutamine Length-Independent Assay. [PDF]

J Huntingtons Dis, 2022
Fodale V, Pintauro R, Daldin M, Spiezia MC, Macdonald D, Bresciani A.   +5 more
europepmc   +1 more source

Fighting the Huntington's Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies. [PDF]

Int J Mol Sci, 2022
Riccardi C, D'Aria F, Digilio FA, Carillo MR, Amato J, Fasano D, De Rosa L, Paladino S, Melone MAB, Montesarchio D, Giancola C.   +10 more
europepmc   +1 more source

A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. [PDF]

G3 (Bethesda), 2021
Huelsmeier J, Walker E, Bakthavachalu B, Ramaswami M.   +3 more
europepmc   +1 more source

Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities. [PDF]

Hum Gene Ther, 2022
Oikemus SR, Pfister EL, Sapp E, Chase KO, Kennington LA, Hudgens E, Miller R, Zhu LJ, Chaudhary A, Mick EO, Sena-Esteves M, Wolfe SA, DiFiglia M, Aronin N, Brodsky MH.   +14 more
europepmc   +1 more source