Results 101 to 110 of about 6,546,213 (228)

Sub-Diffraction Imaging of Huntingtin Protein Aggregates by Fluorescence Blink-Microscopy and Atomic Force Microscopy

ChemPhysChem, 2011
Neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases are all associated with protein misfolding, aggregation, and the accumulation of insoluble amyloid aggregates in neurons.[1] Huntington’s disease is caused by ...
Whitney C. Duim, B. Chen, J. Frydman, W. Moerner   +3 more
semanticscholar   +1 more source

Mutant huntingtin gene-dose impacts on aggregate deposition, DARPP32 expression and neuroinflammation in HdhQ150 mice. [PDF]

PLoS ONE, 2013
Huntington's disease (HD) is an autosomal dominant, progressive and fatal neurological disorder caused by an expansion of CAG repeats in exon-1 of the huntingtin gene.
Douglas Young, Franziska Mayer, Nella Vidotto, Tatjana Schweizer, Ramon Berth, Dorothee Abramowski, Derya R Shimshek, P Herman van der Putten, Peter Schmid   +8 more
doaj   +1 more source

In Vitro and in Vivo Aggregation of a Fragment of Huntingtin Protein Directly Causes Free Radical Production*

Journal of Biological Chemistry, 2011
Background: Neurodegenerative diseases are associated with intracellular protein aggregation and free radical damage. Results: Protein aggregation of polyglutamine-containing proteins directly causes free radical production in vitro and within cells ...
S. Hands, M. Sajjad, Michael J Newton, A. Wyttenbach   +3 more
semanticscholar   +1 more source

Full-length huntingtin constructs for eukaryotic expression of huntingtin protein with different polyQ lengths 2018/05/01

, 2018
Huntingtin structure-function open lab notebook project: Full-length huntingtin constructs for eukaryotic expression of huntingtin protein with different polyQ lengths 2018/05 ...
Loppnau, Peter, Arrowsmith, Cheryl (4928326), Edwards, Aled (4929298), Harding, Rachel (4928305), Harding, Rachel, Loppnau, Peter (4928317), Arrowsmith, Cheryl, Edwards, Aled   +7 more
core   +1 more source

Preventing Formation of Toxic N-Terminal Huntingtin Fragments Through Antisense Oligonucleotide-Mediated Protein Modification

, 2014
Huntington’s disease (HD) is a progressive autosomal dominant disorder, caused by a CAG repeat expansion in the HTT gene, which results in expansion of a polyglutamine stretch at the N-terminal end of the huntingtin protein.
Onno C Meijer (576078), Aartsma-Rus, A., Tran, H.D., Annemieke Aartsma-Rus (33030), Evers, M.M., Roon-Mom, W.M.C. van, Ioannis Zalachoras (576077), Zalachoras, I., Hoang-Dai Tran (576076), Johan T den Dunnen (576079), Ommen, G.J.B. van, Melvin m Evers (576075), Dunnen, J.T. den, Gert-Jan B van Ommen (1783), Meijer, O.C., Willeke Van roon-mom (565176)   +15 more
core   +1 more source

Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction. [PDF]

PLoS ONE, 2013
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin protein. Neuropathology in the basal ganglia and in the cerebral cortex has been linked to the motor and cognitive symptoms ...
Barbara Baldo, Rana Soylu, Asa Petersén
doaj   +1 more source

A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy

Autophagy, 2008
We have recently published the precise definition of an amino-terminal membrane association domain in huntingtin, capable of targeting to the endoplasmic reticulum and late endosomes as well as autophagic vesicles.
R. Atwal, R. Truant
semanticscholar   +1 more source

Interaction of Huntingtin-Associated Protein with Dynactin P150^Glued

, 1998
Huntingtin is the protein product of the gene for Huntington’s disease (HD) and carries a polyglutamine repeat that is expanded in HD (>36 units). Huntingtin-associated protein (HAP1) is a neuronal protein and binds to huntingtin in association with ...
Steven M. Hersch, Xiao-Jiang Li, Shi-Hua Li, Claire-Anne Gutekunst   +3 more
core   +1 more source

The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus

Frontiers in Molecular Biosciences, 2019
Huntington disease is a neurodegenerative disease characterized by a polymorphic tract of polyglutamine repeats in exon 1 of the huntingtin protein, which is thought to be responsible for protein aggregation and neuronal death. The polyglutamine tract is
Havva Yalinca, Charlotte Julie Caroline Gehin, Vladimiras Oleinikovas, Hilal A. Lashuel, Francesco Luigi Gervasio, Francesco Luigi Gervasio, Annalisa Pastore   +6 more
doaj   +1 more source

Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration

PLoS Genetics, 2007
Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be, at least in part, a consequence of protein interactions involving mutant Htt.
Linda S Kaltenbach, Eliana Romero, Robert R Becklin, Rakesh Chettier, Russell Bell, Amit Phansalkar, Andrew Strand, Cameron Torcassi, Justin Savage, Anthony Hurlburt, Guang-Ho Cha, Lubna Ukani, Cindy Lou Chepanoske, Yuejun Zhen, Sudhir Sahasrabudhe, James Olson, Cornelia Kurschner, Lisa M Ellerby, John M Peltier, Juan Botas, Robert E Hughes   +20 more
openaire   +4 more sources