Results 121 to 130 of about 19,163 (188)

Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis. [PDF]

Proc Natl Acad Sci U S A
Sun X, Liu L, Wu C, Li X, Guo J, Zhang J, Guan J, Wang N, Gu L, Yang XW, Li GM.   +10 more
europepmc   +1 more source

Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal α-Helical Region of Htt. [PDF]

Biochemistry, 2020
Arndt JR, Chaibva M, Beasley M, Kiani Karanji A, Ghassabi Kondalaji S, Khakinejad M, Sarver O, Legleiter J, Valentine SJ.   +8 more
europepmc   +1 more source

High Levels of Mutant Huntingtin Protein in Tear Fluid From Huntington's Disease Gene Expansion Carriers. [PDF]

J Mov Disord
Gijs M, Jorna N, Datson N, Beekman C, Dansokho C, Weiss A, Linden DEJ, Oosterloo M.   +7 more
europepmc   +1 more source

Lowering mutant huntingtin protein [PDF]

Nature Reviews Drug Discovery, 2019
openaire   +1 more source

Expression of Human Mutant Huntingtin Protein in Drosophila Hemocytes Impairs Immune Responses. [PDF]

Front Immunol, 2019
Lin YH, Maaroufi HO, Ibrahim E, Kucerova L, Zurovec M.   +4 more
europepmc   +1 more source

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. [PDF]

Elife, 2017
Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ.   +20 more
europepmc   +1 more source

Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington's Disease. [PDF]

Neurosci Bull, 2019
Yang W, Xie J, Qiang Q, Li L, Lin X, Ren Y, Ren W, Liu Q, Zhou G, Wei W, Saiyin H, Ma L.   +11 more
europepmc   +1 more source

Quantification of huntingtin protein species in Huntington's disease patient leukocytes using optimised electrochemiluminescence immunoassays. [PDF]

PLoS One, 2017
Hensman Moss DJ, Robertson N, Farmer R, Scahill RI, Haider S, Tessari MA, Flynn G, Fischer DF, Wild EJ, Macdonald D, Tabrizi SJ.   +10 more
europepmc   +1 more source

Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay. [PDF]

eNeuro, 2018
Baldo B, Sajjad MU, Cheong RY, Bigarreau J, Vijayvargia R, McLean C, Perrier AL, Seong IS, Halliday G, Petersén Å, Kirik D.   +10 more
europepmc   +1 more source

Juvenile Huntington's Disease Skin Fibroblasts Respond with Elevated Parkin Level and Increased Proteasome Activity as a Potential Mechanism to Counterbalance the Pathological Consequences of Mutant Huntingtin Protein. [PDF]

Int J Mol Sci, 2019
Aladdin A, Király R, Boto P, Regdon Z, Tar K.   +4 more
europepmc   +1 more source