Results 131 to 140 of about 6,546,213 (228)

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity

, 2017
Huntington’s disease (HD) is neurodegenerative disorder caused by a polyglutamine expansion in the N-terminal region of the huntingtin protein (N17). Here, we analysed the relative contribution of each phosphorylatable residue in the N17 region (T3, S13 ...
Tiago F. Outeiro (191379), Flaviano Giorgini (58325), Yolanda Pires-Afonso (7813205), Joana Branco-Santos (7756277), Federico Herrera (199602), Gonçalo M. Poças (7813202), Pedro M. Domingos (7813208)   +6 more
core   +3 more sources

Elucidating the Influence of Lipid Composition on Bilayer Perturbations Induced by the N-terminal Region of the Huntingtin Protein. [PDF]

Biophysica, 2023
Gamage YI, Pan J.
europepmc   +1 more source

In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease

, 2008
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien, Roger Albin, Mary Heng, Phillip Wang, Peter Detloff   +4 more
core   +1 more source

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease

Molecular Brain, 2009
Background Huntington's disease (HD) is an inherited neurogenerative disease caused by an abnormal expansion of glutamine repeats in the huntingtin protein.
Pineda Jose R, Pardo Raúl, Zala Diana, Yu Hua, Humbert Sandrine, Saudou Frédéric   +5 more
doaj   +1 more source

Parameters Affecting the Pathogenicity of Huntingtin Protein

, 2013
This work explores mechanisms of pathology in Huntington's Disease (HD) in an attempt to identify attractive therapeutic targets. By inserting the gene for human huntingtin (HTT) into the genome of the fruit fly Drosophila melanogaster, we have ...
Barbaro, Brett Anthony
core  

Cytotoxicity of Mutant Huntingtin Fragment in Yeast Can Be Modulated by the Expression Level of Wild Type Huntingtin Fragment

, 2016
Conflicting reports exist in the literature regarding the role of wild-type huntingtin in determining the toxicity of the aggregated, mutant huntingtin in Huntington’s disease (HD).
Ankan Kumar Bhadra (144866), Ipsita Roy (1530622), Aliabbas Ahmedbhai Saleh (1831750)   +2 more
core   +1 more source

Biochemical and Biophysical Characterization of Huntingtin [PDF]

, 2016
Huntington’s disease (HD) is a fatal autosomal dominant neurodegenerative disease. HD has no cure, and patients pass away 10-20 years after the onset of symptoms.
Owens, Gwen Ellen
core   +1 more source

Biomarkers for Huntington's disease: an update

, 2012
Huntington's disease (HD) is a devastating autosomal-dominant neurodegenerative condition caused by a CAG repeat expansion in the gene encoding huntingtin which is characterised by progressive motor impairment, cognitive decline and neuropsychiatric ...
Wild, EJ, Tabrizi, SJ, Scahill, RI
core  

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

, 1997
We report the discovery of the huntingtin interacting protein I (HIP-I) which binds specifically to the N-terminus of human huntingtin, both in the two-hybrid screen and in in vitro binding experiments.
Rovira, C., Lehrach, H., Colicelli, J., Tait, D., Walter, S., Hasenbank, R., Scherzinger, E., Wanker, E.E.   +7 more
core   +1 more source

Investigating curvature sensing by the Nt17 domain of Huntingtin protein

ACS Chemical Neuroscience
Abstract Nt17, the N-terminal domain of the huntingtin protein (htt), has garnered significant attention for its role in htt’s membrane binding and aggregation processes. Previous studies have identified a nuclear export sequence within the Nt17 domain and demonstrated its localization at various ...
Neha Nanajkar, Abhilash Sahoo, Shelli L. Frey, Silvina Matysiak   +3 more
openaire   +2 more sources