Results 151 to 160 of about 37,064 (267)

Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide. [PDF]

Proc Natl Acad Sci U S A, 2022
Song H, Wang C, Zhu C, Wang Z, Yang H, Wu P, Cui X, Botas J, Dang Y, Ding Y, Fei Y, Lu B.   +11 more
europepmc   +1 more source

Data from Huntingtin Interacting Protein 1 Is a Novel Brain Tumor Marker that Associates with Epidermal Growth Factor Receptor

, 2023
Sarah V. Bradley, Eric C. Holland, Grace Y. Liu, Dafydd G. Thomas, Teresa S. Hyun, Theodora S. Ross   +5 more
openalex   +1 more source

Selective observation of semi-rigid non-core residues in dynamically complex mutant huntingtin protein fibrils. [PDF]

J Struct Biol X, 2022
Matlahov I, Boatz JC, van der Wel PCA.
europepmc   +1 more source

Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington's disease models. [PDF]

Cell Biosci, 2022
Latoszek E, Wiweger M, Ludwiczak J, Dunin-Horkawicz S, Kuznicki J, Czeredys M.   +5 more
europepmc   +1 more source

Restoration from polyglutamine toxicity after free electron laser irradiation of neuron-like cells [PDF]

, 2019
学位記番号 ...
Mohara, Miho, モハラ, ミホ, 茂原, 美穂   +2 more
core  

Investigating curvature sensing by the Nt17 domain of Huntingtin protein

ACS Chemical Neuroscience
Abstract Nt17, the N-terminal domain of the huntingtin protein (htt), has garnered significant attention for its role in htt’s membrane binding and aggregation processes. Previous studies have identified a nuclear export sequence within the Nt17 domain and demonstrated its localization at various ...
Neha Nanajkar, Abhilash Sahoo, Shelli L. Frey, Silvina Matysiak   +3 more
openaire   +2 more sources

N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate. [PDF]

J Biol Chem, 2021
Gottlieb L, Guo L, Shorter J, Marmorstein R.   +3 more
europepmc   +1 more source

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage [PDF]

, 2017
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD)
Albin, Roger, Augood, Sarah J., Bates, Gillian P., Becanovic, Kristina, Cha, Jang-Ho J., Delorenzi, Mauro, Dunnett, Stephen B., Faull, Richard L.M., Ferrante, Robert J., Goldstein, Darlene R., Hannan, Anthony J., Hayden, Michael R., Hodges, Angela, Jones, Lesley, Kooperberg, Charles, Kuhn, Alexandre, Leavitt, Blair R., Luthi-Carter, Ruth, Olson, James M., Pouladi, Mahmoud A., Sathasivam, Kirupa, Sengstag, Thierry, Shelbourne, Peggy, Strand, Andrew D.   +23 more
core  

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source

Huntingtin-Interacting Protein 1 Influences Worm and Mouse Presynaptic Function and ProtectsCaenorhabditis elegansNeurons against Mutant Polyglutamine Toxicity [PDF]

, 2007
J. Alex Parker, Martina Metzler, John Georgiou, Marilyne Mage, John Roder, Ann M. Rose, Michael R. Hayden, Christian Néri   +7 more
openalex   +1 more source