Results 151 to 160 of about 6,546,213 (228)

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.

Journal of Clinical Investigation, 2015
E. Wild, R. Boggio, D. Langbehn, N. Robertson, S. Haider, James R. C. Miller, H. Zetterberg, B. Leavitt, R. Kuhn, S. Tabrizi, D. Macdonald, A. Weiss   +11 more
semanticscholar   +1 more source

Autophagy-Induced Nanoparticle-Based Clearing of Toxic Huntingtin Protein Aggregates from Neuron Cells

Clearing of toxic huntingtin protein aggregates from neuron cells is critical for treatment of Huntington’s disease. However, this is very challenging and requires the control of intracellular processes and associated biochemical activities.
Pankaj Seth (226669), Guneet Kaur (5210957), Nihar R. Jana (207864), Nikhil R. Jana (1268586), Ankan Kumar Sarkar (11909137)   +4 more
core   +1 more source

<i>cnnm-5</i> knockdown improves proteostasis of mutant Huntingtin protein in <i>C. elegans</i>. [PDF]

MicroPubl Biol
Hull M, Mills J.
europepmc   +1 more source

Developmental and physiological impacts of pathogenic human huntingtin protein in the nervous system. [PDF]

Neurobiol Dis
Hana TA, Mousa VG, Lin A, Haj-Hussein RN, Michael AH, Aziz MN, Kamaridinova SU, Basnet S, Ormerod KG.   +8 more
europepmc   +1 more source

A role of cellular translation regulation associated with toxic Huntingtin protein. [PDF]

Cell Mol Life Sci, 2020
Joag H, Ghatpande V, Desai M, Sarkar M, Raina A, Shinde M, Chitale R, Deo A, Bose T, Majumdar A.   +9 more
europepmc   +1 more source

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex

Human Molecular Genetics, 2016
Tamara Maiuri, Andrew J. Mocle, C. L. Hung, Jianrun Xia, W. V. van Roon-Mom, R. Truant   +5 more
semanticscholar   +1 more source

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays. [PDF]

Brain Commun
Landles C, Osborne GF, Phillips J, Canibano-Pico M, Nita IM, Ali N, Bobkov K, Greene JR, Sathasivam K, Bates GP.   +9 more
europepmc   +1 more source

Chemical mutagenesis of Caenorhabditis elegans uncovers genetic modifiers of huntingtin protein aggregation. [PDF]

MicroPubl Biol, 2020
Ung H, Hall R, Kikis E.
europepmc   +1 more source

Differential Effects of Post-translational Modifications on the Membrane Interaction of Huntingtin Protein. [PDF]

ACS Chem Neurosci
Zhang Z, Gehin C, Abriata LA, Dal Peraro M, Lashuel H.   +4 more
europepmc   +1 more source

The Huntingtin Transport Complex

A dynamic network of scaffolding molecules, adaptor proteins, and motor proteins work together to orchestrate the movement of proteins, mRNA, and vesicular cargoes. Defects in intracellular transport can often lead to neurodegeneration.
Hendricks, Adam G., Turkalj, Brooke A., Prowse, Emily N.P.; id_orcid, Gursu, Lale   +3 more
core   +1 more source