Results 181 to 190 of about 6,546,213 (228)

AMT-130 gene therapy: a promising disease-modifying approach for Huntington's disease. [PDF]

Ann Med Surg (Lond)
Mwape C, Qureshi AA, Saeed MZ, Fatima A, Jamil A, Mahmood H, Batool A, Khan AM.   +7 more
europepmc   +1 more source

Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin. [PDF]

JCI Insight
Jeong H, Qin Y, Xu F, Trajkovic K, Kim MJ, Marotta N, Hamada K, Allada R, Yang S, Krainc D.   +9 more
europepmc   +1 more source

Erratum for the Research Article "Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread" by S. Dagar <i>et al</i>.

Sci Adv
europepmc   +1 more source

Huntingtin: A Protein with a Peculiar Solvent Accessible Surface

International Journal of Molecular Sciences, 2021
Taking advantage of the last cryogenic electron microscopy structure of human huntingtin, we explored with computational methods its physicochemical properties, focusing on the solvent accessible surface of the protein and highlighting a quite interesting mix of hydrophobic and hydrophilic patterns, with the prevalence of the latter ones.
Giulia Babbi, Castrense Savojardo, Pier Luigi Martelli   +2 more
exaly   +4 more sources

Accelerating the clearance of mutant huntingtin protein aggregates through autophagy induction by europium hydroxide nanorods

Biomaterials, 2014
Autophagy is one of the well-known pathways to accelerate the clearance of protein aggregates, which contributes to the therapy of neurodegenerative diseases.
Pengfei Wei, Li Zhang, Susheel Kumar Nethi   +2 more
exaly   +3 more sources

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Huntington disease and the huntingtin protein.

Progress in Molecular Biology and Translational Science, 2012
Huntington disease (HD) is a devastating neurodegenerative disease that derives from CAG repeat expansion in the huntingtin gene. The clinical syndrome consists of progressive personality changes, movement disorder, and dementia and can develop in children and adults.
Zhiqiang Zheng, M. Diamond
semanticscholar   +3 more sources

Arfaptin 2 regulates the aggregation of mutant huntingtin protein

Nature Cell Biology, 2002
Huntington's disease (HD) is an inherited neurodegenerative disorder. Here we demonstrate that expression of arfaptin 2/POR1 (partner of Rac1) in cultured cells induces the formation of pericentriolar and nuclear aggregates, which morphologically ...
P. Peters, Ke Ning, Felipe Palacios, R. Boshans, A. Kazantsev, L. Thompson, B. Woodman, G. Bates, C. D’Souza-Schorey   +8 more
semanticscholar   +2 more sources

Huntingtin-protein interactions and the pathogenesis of Huntington's disease.

Trends in Genetics, 2004
At least nine inherited neurodegenerative diseases share a polyglutamine expansion in their respective disease proteins. These diseases show distinct neuropathological changes, suggesting that protein environment and protein-protein interactions play an important role in the specific neuropathology.
Shihua Li, Xiao-Jiang Li
semanticscholar   +3 more sources

Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains

Cellular and Molecular Life Sciences, 2022
Huntingtin-associated protein 1 (HAP1) is the first identified protein whose function is affected by its abnormal interaction with mutant huntingtin (mHTT), which causes Huntington disease. However, the expression patterns of Hap1 and Htt in the rodent brain are not correlated.
Xingxing Chen, Yize Sun, Laiqiang Chen, Xiu-sheng Chen, Mingtian Pan, Yiran Zhang, Qi Wang, Weili Yang, Peng Yin, Dajian He, Xiangyu Guo, Su Yang, Yan Zeng, Sen Yan, Xiao-Jiang Li, Shihua Li   +15 more
openaire   +2 more sources

Huntingtin protein: A new option for fixing the Huntington's disease countdown clock

Neuropharmacology, 2018
&NA; Huntington's disease is a dreadful, incurable disorder. It springs from the autosomal dominant mutation in the first exon of the HTT gene, which encodes for the huntingtin protein (HTT) and results in progressive neurodegeneration. Thus far, all the
M. Caterino, T. Squillaro, D. Montesarchio, A. Giordano, C. Giancola, M. Melone   +5 more
semanticscholar   +1 more source