Results 161 to 170 of about 37,064 (267)

The biological function of the Huntingtin protein and its relevance to Huntington’s Disease pathology [PDF]

, 2011
available in PMC 2011 December 14.Huntington’s Disease is an adult-onset dominant heritable disorder characterized by progressive psychiatric disruption, cognitive deficits, and loss of motor coordination.
Littleton, J. Troy, Schulte, Joost
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Huntingtin Protein Measurement [PDF]

, 2020
openaire   +1 more source

Fighting the Huntington's Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies. [PDF]

Int J Mol Sci, 2022
Riccardi C, D'Aria F, Digilio FA, Carillo MR, Amato J, Fasano D, De Rosa L, Paladino S, Melone MAB, Montesarchio D, Giancola C.   +10 more
europepmc   +1 more source

A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. [PDF]

G3 (Bethesda), 2021
Huelsmeier J, Walker E, Bakthavachalu B, Ramaswami M.   +3 more
europepmc   +1 more source

Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival [PDF]

, 2002
Dinesh S. Rao, Teresa S. Hyun, Priti D. Kumar, Ikuko F. Mizukami, Mark A. Rubin, Peter C. Lucas, Martin G. Sanda, Theodora S. Ross   +7 more
openalex   +1 more source

Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease [PDF]

, 2023
Longbin Liu, Karine Malagu, Alan F. Haughan, Vinod Khetarpal, Andrew J. Stott, William Esmieu, Huw D. Vater, Stephen J. Webster, Amanda J. Van de Poël, Cole Clissold, Brett Cosgrove, Benjamin Sutton, Jonathan A. Spencer, Perla Breccia, Emanuela Gancia, S Bonomo, Tammy Ladduwahetty, Ovadia Lazari, Hiral Patel, Helen C. Atton, Steve Clifton, Daniel Mota‐Rojas, Dario Magnani, Amy O’Neill, Marta Stebbeds, Natsuko Macabuag, Daniel Todd, María Eugenia Herva, Philip B. Mitchell, Mijke Visser, Sara Compte-Sancerni, Laure Grand Moursel, Marta da Silva, Eva Kritikou, Taneli Heikkinen, Tamuna Bolkvadze, Valentina Fodale, D. Spadafora, Manuel Daldin, Alberto Bresciani, John E. Mangette, Elizabeth M. Doherty, Matthew R. Lee, Todd Herbst, Edith Monteagudo, Douglas Macdonald, Nikolay V. Plotnikov, M.G. Chambers, George McAllister, Ignacio Muñoz-Sanjuán, Celia Dominguez   +50 more
openalex   +1 more source

Differential effects of overexpression of mutant huntingtin and TDP-43 in agouti-related protein neurons in the arcuate nucleus of the hypothalamus in mice

Oraha, Jennifer, Wagner, Ronja, Bergh, Sofia, Lee, Nicola J, Kirik, Deniz, Petersén, Åsa   +5 more
openalex   +2 more sources

Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities. [PDF]

Hum Gene Ther, 2022
Oikemus SR, Pfister EL, Sapp E, Chase KO, Kennington LA, Hudgens E, Miller R, Zhu LJ, Chaudhary A, Mick EO, Sena-Esteves M, Wolfe SA, DiFiglia M, Aronin N, Brodsky MH.   +14 more
europepmc   +1 more source

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila [PDF]

, 2003
Shermali Gunawardena, Lu‐Shiun Her, Richard G. Brusch, Robert A. Laymon, Ingrid R. Niesman, Beth Gordesky-Gold, Louis Sintasath, Nancy M. Bonini, Lawrence S.B. Goldstein   +8 more
openalex   +1 more source

2008 Progress Report on Brain Research [PDF]

, 2008
Highlights new research on various disorders, nervous system injuries, neuroethics, neuroimmunology, pain, sense and body function, stem cells and neurogenesis, and thought and memory.
Eve Marder, Mahlon R. DeLong, Michael S. Gazzaniga, Thomas Wichmann   +3 more
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