Results 141 to 150 of about 19,163 (188)

Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin. [PDF]

JCI Insight
Jeong H, Qin Y, Xu F, Trajkovic K, Kim MJ, Marotta N, Hamada K, Allada R, Yang S, Krainc D.   +9 more
europepmc   +1 more source

Erratum for the Research Article "Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread" by S. Dagar <i>et al</i>.

Sci Adv
europepmc   +1 more source

Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression [PDF]

Pharmaceutics, 2021
CARLOS Barrero, Xu-Qiao Chen, Salim Merali   +2 more
exaly   +2 more sources

Huntingtin: A Protein with a Peculiar Solvent Accessible Surface

International Journal of Molecular Sciences, 2021
Taking advantage of the last cryogenic electron microscopy structure of human huntingtin, we explored with computational methods its physicochemical properties, focusing on the solvent accessible surface of the protein and highlighting a quite interesting mix of hydrophobic and hydrophilic patterns, with the prevalence of the latter ones.
Pier Luigi Martelli, Castrense Savojardo, Rita Casadio   +2 more
exaly   +3 more sources

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2017
Hilal Lashuel, Elena Cattaneo, Squitieri F   +2 more
exaly   +2 more sources

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Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains

Cellular and Molecular Life Sciences, 2022
Huntingtin-associated protein 1 (HAP1) is the first identified protein whose function is affected by its abnormal interaction with mutant huntingtin (mHTT), which causes Huntington disease. However, the expression patterns of Hap1 and Htt in the rodent brain are not correlated.
Xingxing Chen, Yize Sun, Laiqiang Chen, Xiu-sheng Chen, Mingtian Pan, Yiran Zhang, Qi Wang, Weili Yang, Peng Yin, Dajian He, Xiangyu Guo, Su Yang, Yan Zeng, Sen Yan, Xiao-Jiang Li, Shihua Li   +15 more
openaire   +2 more sources

Huntington Disease and the Huntingtin Protein

2012
Huntington disease (HD) is a devastating neurodegenerative disease that derives from CAG repeat expansion in the huntingtin gene. The clinical syndrome consists of progressive personality changes, movement disorder, and dementia and can develop in children and adults.
Zhiqiang, Zheng, Marc I, Diamond
openaire   +2 more sources

Huntingtin-Associated Proteins

2001
Huntington’s disease (HD), with its writhing dancelike movements (chorea) and cardinal loss of neurons in the striatum (1), is the result of an unstable expanded CAG trinucleotide repeat that lengthens a variable glutamine tract in a novel protein called huntingtin (HD) (2).
Marcy E. MacDonald, Lucius Passani, Paige Hilditch-Maguire   +2 more
openaire   +1 more source

Glassy dynamics in mutant huntingtin proteins

The Journal of Chemical Physics, 2018
Causative to the neurodegenerative Huntington’s disease (HD), a mutational huntingtin (HTT) protein consists of an unusual expansion on the poly-glutamine (polyQ) region in the first exon (exon-1) domain. Despite its significance on HD progression, the structural role of the exon-1 with the polyQ region is still elusive.
Hongsuk Kang, Binquan Luan, Ruhong Zhou
openaire   +2 more sources

Small-Molecule Disruptors of Mutant Huntingtin–Calmodulin Protein–Protein Interaction Attenuate Deleterious Effects of Mutant Huntingtin

ACS Chemical Neuroscience, 2022
Huntington's disease is a progressive and lethal neurodegenerative disease caused by an increased CAG repeat mutation in exon 1 of the huntingtin gene (mutant huntingtin). Current drug treatments provide only limited symptomatic relief without impacting disease progression.
Khushboo Kapadia, Ashley E. Trojniak, Kenneth B. Guzmán Rodríguez, Nicholas J. Klus, Coral Huntley, Peter McDonald, Anuradha Roy, Kevin J. Frankowski, Jeffrey Aubé, Nancy A. Muma   +9 more
openaire   +2 more sources