Results 141 to 150 of about 6,546,213 (228)

Selective observation of semi-rigid non-core residues in dynamically complex mutant huntingtin protein fibrils. [PDF]

J Struct Biol X, 2022
Matlahov I, Boatz JC, van der Wel PCA.
europepmc   +1 more source

Cysteine String Protein (CSP) Inhibition of N-type Calcium Channels Is Blocked by Mutant Huntingtin

, 2003
Cysteine string protein (CSP), a 34-kDa molecular chaperone, is expressed on synaptic vesicles in neurons and on secretory vesicles in endocrine, neuroendocrine, and exocrine cells.
Miller, Linda C., Zamponi, Gerald W., Swayne, Leigh Anne, Chen, Lina, Muchowski, Paul J., Feng, Zhong-Ping, Wacker, Jennifer L., Braun, Janice E. A.   +7 more
core   +1 more source

N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate. [PDF]

J Biol Chem, 2021
Gottlieb L, Guo L, Shorter J, Marmorstein R.   +3 more
europepmc   +1 more source

Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease. [PDF]

J Huntingtons Dis, 2022
Podvin S, Rosenthal SB, Poon W, Wei E, Fisch KM, Hook V.   +5 more
europepmc   +1 more source

Quantifying Huntingtin Protein in Human Cerebrospinal Fluid Using a Novel Polyglutamine Length-Independent Assay. [PDF]

J Huntingtons Dis, 2022
Fodale V, Pintauro R, Daldin M, Spiezia MC, Macdonald D, Bresciani A.   +5 more
europepmc   +1 more source

Fighting the Huntington's Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies. [PDF]

Int J Mol Sci, 2022
Riccardi C, D'Aria F, Digilio FA, Carillo MR, Amato J, Fasano D, De Rosa L, Paladino S, Melone MAB, Montesarchio D, Giancola C.   +10 more
europepmc   +1 more source

The sHsp expression signature in the brain and modulation in models of chronic neurodegeneration

, 2010
Intrinsic protein folding pathways are modulated by molecular chaperones, such as the diversegroup of heat shock proteins (Hsps). Among these is the small heat shock protein (sHsp)family which in the mammalian genome consists of 10 low molecular weight ...
Quraishe, Shmma
core  

A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. [PDF]

G3 (Bethesda), 2021
Huelsmeier J, Walker E, Bakthavachalu B, Ramaswami M.   +3 more
europepmc   +1 more source

Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities. [PDF]

Hum Gene Ther, 2022
Oikemus SR, Pfister EL, Sapp E, Chase KO, Kennington LA, Hudgens E, Miller R, Zhu LJ, Chaudhary A, Mick EO, Sena-Esteves M, Wolfe SA, DiFiglia M, Aronin N, Brodsky MH.   +14 more
europepmc   +1 more source

Huntingtin-Interacting Protein 1 [PDF]

, 2020
openaire   +1 more source