Results 191 to 200 of about 6,546,213 (228)

Glassy dynamics in mutant huntingtin proteins

The Journal of Chemical Physics, 2018
Causative to the neurodegenerative Huntington’s disease (HD), a mutational huntingtin (HTT) protein consists of an unusual expansion on the poly-glutamine (polyQ) region in the first exon (exon-1) domain. Despite its significance on HD progression, the structural role of the exon-1 with the polyQ region is still elusive.
Hongsuk Kang, Binquan Luan, Ruhong Zhou
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Huntingtin-Associated Proteins

2001
Huntington’s disease (HD), with its writhing dancelike movements (chorea) and cardinal loss of neurons in the striatum (1), is the result of an unstable expanded CAG trinucleotide repeat that lengthens a variable glutamine tract in a novel protein called huntingtin (HD) (2).
Marcy E. MacDonald, Lucius Passani, Paige Hilditch-Maguire   +2 more
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Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1)

Journal of Human Genetics, 1998
Huntington disease (HD) is an inherited neurodegenerative disorder which is associated with CAG expansion in the coding region of the gene for huntingtin protein.
Naohiko Seki, Masa-Aki Muramatsu, Sumio Sugano   +2 more
exaly   +1 more source

New anti-huntingtin monoclonal antibodies: implications for huntingtin conformation and its binding proteins

Brain Research Bulletin, 2001
We produced eight anti-huntingtin (Htt) monoclonal antibodies (mAbs), several of which have novel binding patterns. Peptide array epitope mapping shows that mAbs MW1-6 specifically bind the polyQ domain of Htt exon 1. On Western blots of extracts from mutant Htt knock-in mouse brain and Huntington's disease lymphoblastoma cell lines, MW1-5 all strongly
Ko, Jan, Ou, Susan, Patterson, Paul H.
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Effect of Pesticides on the Aggregation of Mutant Huntingtin Protein

Molecular Neurobiology, 2012
The classical reports on neurodegeneration concentrate on studying disruption of signalling cascades. Although it is now well recognized that misfolding and aggregation of specific proteins are associated with a majority of these diseases, their role in aggravating the symptoms is not so well understood. Huntington's disease (HD) is a neurodegenerative
Ruhi S, Deshmukh, Rajeev K, Chaudhary, Ipsita, Roy   +2 more
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Aggregate-centered redistribution of proteins by mutant huntingtin

Biochemical and Biophysical Research Communications, 2007
Huntingtin is a widely expressed 350-kDa cytosolic multidomain of unknown function. Aberrant expansion of the polyglutamine tract located in the N-terminal region of huntingtin results in Huntington's disease. The presence of insoluble huntingtin inclusions in the brains of patients is one of the hallmarks of Huntington's disease.
Leigh Anne, Swayne, Janice E A, Braun
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Huntingtin interacting protein HYPK is intrinsically unstructured

Proteins: Structure, Function, and Bioinformatics, 2007
AbstractTo characterize HYPK, originally identified as a novel huntingtin (Htt) interacting partner by yeast two hybrid assay, we used various biophysical and biochemical techniques. The molecular weight of the protein, determined by gel electrophoresis, was found to be about 1.3‐folds (∼22 kDa) higher than that obtained from mass spectrometric ...
Swasti, Raychaudhuri, Pritha, Majumder, Somosree, Sarkar, Kalyan, Giri, Debashis, Mukhopadhyay, Nitai P, Bhattacharyya   +5 more
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Huntingtin is associated with cytomatrix proteins at the presynaptic terminal

Molecular and Cellular Neuroscience, 2014
Huntington's disease (HD) is a single gene disorder produced by expansion of the gene encoding huntingtin (htt), a large protein with features of a multi-functional scaffold. Expansion of htt's polyglutamine domain induces novel, toxic interactions and likely also disrupts normal htt function.
Jia, Yao, Shao-En, Ong, Sandra, Bajjalieh   +2 more
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Apoptotic Regulation by the Huntingtin Protein

2001
Title page and contents Chapter I - Introduction 1 A Matter of Death 1 1.1 Necrosis 1 1.1.1 Morphological Features of Necrosis 2 1.2 Apoptosis 2 1.2.1 Morphological Features of Apoptosis 3 1.3 Apoptosis and Necrosis: A Continuum? 4 2 The Molecular Components of Apoptosis 2.1 Death Receptors 5 2.2 Bcl-2 Family 6 2.3 Apaf-1 Family 7 2.4 Caspases 7 2.5 ...
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[Protein-Protein Interactions of Huntingtin in the Hippocampus].

Molekuliarnaia biologiia, 2018
Huntingtin (HTT) occurs in the neuronal cytoplasm and can interact with structural elements of synapses. Huntington's disease (HD) results from pathological expansion of a polyglutamine stretch in the HTT molecule, being probably associated with aberrant protein-protein interactions.
A L, Proskura, S O, Vechkapova, T A, Zapara, A S, Ratushniak   +3 more
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