Results 191 to 200 of about 37,064 (267)

The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain. [PDF]

Structure, 2020
Jung T, Shin B, Tamo G, Kim H, Vijayvargia R, Leitner A, Marcaida MJ, Astorga-Wells J, Jung R, Aebersold R, Peraro MD, Hebert H, Seong IS, Song JJ.   +13 more
europepmc   +1 more source

Additional file 3 of The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin

, 2020
Manuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang Baumeister, Qiang Guo, Rubén Fernández‐Busnadiego, Andrei N. Lupas, Stefan Kochanek   +8 more
openalex   +1 more source

Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis. [PDF]

Proc Natl Acad Sci U S A
Sun X, Liu L, Wu C, Li X, Guo J, Zhang J, Guan J, Wang N, Gu L, Yang XW, Li GM.   +10 more
europepmc   +1 more source

Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal α-Helical Region of Htt. [PDF]

Biochemistry, 2020
Arndt JR, Chaibva M, Beasley M, Kiani Karanji A, Ghassabi Kondalaji S, Khakinejad M, Sarver O, Legleiter J, Valentine SJ.   +8 more
europepmc   +1 more source

High Levels of Mutant Huntingtin Protein in Tear Fluid From Huntington's Disease Gene Expansion Carriers. [PDF]

J Mov Disord
Gijs M, Jorna N, Datson N, Beekman C, Dansokho C, Weiss A, Linden DEJ, Oosterloo M.   +7 more
europepmc   +1 more source

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex [PDF]

, 2016
Tamara Maiuri, Andrew J. Mocle, Claudia Lin-Kar Hung, Jianrun Xia, Willeke van Roon‐Mom, Ray Truant   +5 more
openalex   +1 more source

Huntingtin Interacting Protein 1 Induces Apoptosis via a Novel Caspase-dependent Death Effector Domain

, 2000
Abigail S. Hackam, Ayman S. Yassa, Roshni R. Singaraja, Martina Metzler, Claire-Anne Gutekunst, Lu Gan, Simon C. Warby, Cheryl L. Wellington, John P. Vaillancourt, Nansheng Chen, François G. Gervais, Lynn A. Raymond, Donald W. Nicholson, Michael R. Hayden   +13 more
openalex   +1 more source

Additional file 1 of Differential effects of overexpression of mutant huntingtin and TDP-43 in agouti-related protein neurons in the arcuate nucleus of the hypothalamus in mice

Oraha, Jennifer, Wagner, Ronja, Bergh, Sofia, Lee, Nicola J, Kirik, Deniz, Petersén, Åsa   +5 more
openalex   +1 more source

Expression of Human Mutant Huntingtin Protein in Drosophila Hemocytes Impairs Immune Responses. [PDF]

Front Immunol, 2019
Lin YH, Maaroufi HO, Ibrahim E, Kucerova L, Zurovec M.   +4 more
europepmc   +1 more source

Design and characterisation of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems [PDF]

, 2018
Rachel Harding, P. Loppnau, Suzanne Ackloo, Alexander Lemak, Ashley Hutchinson, Brittany Hunt, Alex S. Holehouse, Jolene Caifeng Ho, Lixin Fan, Leticia Toledo‐Sherman, Alma Seitova, C.H. Arrowsmith   +11 more
openalex   +1 more source