Results 181 to 190 of about 19,301 (228)

Kinetic Mechanism of Substoichiometric Inhibition of Huntingtin Exon‐1 Protein Aggregation by Selenium Nanoparticles

Francesco Torricella, Vitali Tugarinov, G. Marius Clore   +2 more
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Proteasomal Degradation of Mutant Huntingtin Exon1 Regulates Autophagy. [PDF]

Cells
Folger A, Chen C, Gonzalez P, Owutey SL, Wang Y.   +4 more
europepmc   +1 more source

A new hope for patients with Huntington's disease? [PDF]

EClinicalMedicine
eClinicalMedicine.
europepmc   +1 more source

In Vivo PET Imaging of [¹⁸F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington Disease. [PDF]

J Nucl Med
Zajicek F, Elvas F, Miranda A, Akkermans J, Verhaeghe J, Dominguez C, Doot R, Khetarpal V, Bard J, Liu L, Staelens S, Bertoglio D.   +11 more
europepmc   +1 more source

Regulation of nuclear transport of the transcriptional factor REST improves axon regeneration in peripheral nerves. [PDF]

Mol Med Rep
Suzuki T, Naito K, Kubota D, Ueno Y, Negishi-Koga T, Yamamoto Y, Kawakita S, Imazu N, Kawamura K, Hattori N, Ishijima M.   +10 more
europepmc   +1 more source

Brain-Derived Neurotrophic Factor Trafficking via the Regulated Secretory Pathway: Mechanisms and Disease Implications. [PDF]

Mol Neurobiol
Ewell SN.
europepmc   +1 more source

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Small-Molecule Disruptors of Mutant Huntingtin–Calmodulin Protein–Protein Interaction Attenuate Deleterious Effects of Mutant Huntingtin

ACS Chemical Neuroscience, 2022
Huntington's disease is a progressive and lethal neurodegenerative disease caused by an increased CAG repeat mutation in exon 1 of the huntingtin gene (mutant huntingtin). Current drug treatments provide only limited symptomatic relief without impacting disease progression.
Khushboo Kapadia, Ashley E. Trojniak, Kenneth B. Guzmán Rodríguez, Nicholas J. Klus, Coral Huntley, Peter McDonald, Anuradha Roy, Kevin J. Frankowski, Jeffrey Aubé, Nancy A. Muma   +9 more
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Glassy dynamics in mutant huntingtin proteins

The Journal of Chemical Physics, 2018
Causative to the neurodegenerative Huntington’s disease (HD), a mutational huntingtin (HTT) protein consists of an unusual expansion on the poly-glutamine (polyQ) region in the first exon (exon-1) domain. Despite its significance on HD progression, the structural role of the exon-1 with the polyQ region is still elusive.
Hongsuk Kang, Binquan Luan, Ruhong Zhou
openaire   +2 more sources

New anti-huntingtin monoclonal antibodies: implications for huntingtin conformation and its binding proteins

Brain Research Bulletin, 2001
We produced eight anti-huntingtin (Htt) monoclonal antibodies (mAbs), several of which have novel binding patterns. Peptide array epitope mapping shows that mAbs MW1-6 specifically bind the polyQ domain of Htt exon 1. On Western blots of extracts from mutant Htt knock-in mouse brain and Huntington's disease lymphoblastoma cell lines, MW1-5 all strongly
Ko, Jan, Ou, Susan, Patterson, Paul H.
openaire   +3 more sources

Huntingtin-Associated Proteins

2001
Huntington’s disease (HD), with its writhing dancelike movements (chorea) and cardinal loss of neurons in the striatum (1), is the result of an unstable expanded CAG trinucleotide repeat that lengthens a variable glutamine tract in a novel protein called huntingtin (HD) (2).
Marcy E. MacDonald, Lucius Passani, Paige Hilditch-Maguire   +2 more
openaire   +1 more source