Results 21 to 30 of about 32,987 (207)

Variation within the Huntington's disease gene influences normal brain structure. [PDF]

PLoS ONE, 2012
Genetics of the variability of normal and diseased brain structure largely remains to be elucidated. Expansions of certain trinucleotide repeats cause neurodegenerative disorders of which Huntington's disease constitutes the most common example. Here, we
Mark Mühlau, Juliane Winkelmann, Dan Rujescu, Ina Giegling, Nikolaos Koutsouleris, Christian Gaser, Milan Arsic, Adolph Weindl, Maximilian Reiser, Eva M Meisenzahl   +9 more
doaj   +1 more source

Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in Aplysia. [PDF]

PLoS ONE, 2014
Patients with Huntington's disease exhibit memory and cognitive deficits many years before manifesting motor disturbances. Similarly, several studies have shown that deficits in long-term synaptic plasticity, a cellular basis of memory formation and ...
Yun-Beom Choi, Beena M Kadakkuzha, Xin-An Liu, Komolitdin Akhmedov, Eric R Kandel, Sathyanarayanan V Puthanveettil   +5 more
doaj   +1 more source

In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease

Heliyon, 2021
Huntington's disease is a neurodegenerative disease caused by CAG repeat in the first exon of HTT (Huntingtin) gene, leading to abnormal form of Htt protein containing enlarged polyglutamine strands of variable length that stick together to form ...
Harleen Kohli, Pravir Kumar, Rashmi K. Ambasta   +2 more
doaj  

Bioinformatics analysis of the molecular mechanism underlying Huntington's disease

Journal of Integrative Neuroscience, 2019
We explore the underlying molecular mechanisms and to identify key molecules in Huntington's disease by utilizing bioinformatics methods. The gene expression profile of GSE3621 was extracted from the gene expression omnibus.
Zhimin Wang, Xiaoyu Dong, Shuyan Cong
doaj   +1 more source

A Primate Model of Huntington'S Disease: Functional Neural Transplantation and Ct-Guided Stereotactic Procedures

Cell Transplantation, 1992
In this article, we show that 1) computed tomographic (CT)-guided stereotactic infusion of an excitotoxin into the striatum of a nonhuman primate provides a useful neuropathologic and behavioral model for Huntington's disease. 2) High-resolution positron
James M. Schumacher, Philippe Hantraye, Anna-Lisa Brownell, Danielle Riche, Bertha K. Madras, Paula D. Davenport, Mariannick Maziere, David R. Elmaleh, Gordon L. Brownell, Ole Isacson   +9 more
doaj   +1 more source

Therapeutic advances in neural regeneration for Huntington's disease

Neural Regeneration Research
Huntington's disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the HTT gene which is responsible for the production of the huntingtin (Htt) protein. In physiological conditions,
Francesco D'Egidio, Vanessa Castelli, Giorgia Lombardozzi, Fabrizio Ammannito, Annamaria Cimini, Michele d'Angelo   +5 more
doaj   +1 more source

A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.

PLoS Genetics, 2012
A genome-scale RNAi screen was performed in a mammalian cell-based assay to identify modifiers of mutant huntingtin toxicity. Ontology analysis of suppressor data identified processes previously implicated in Huntington's disease, including proteolysis ...
John P Miller, Bridget E Yates, Ismael Al-Ramahi, Ari E Berman, Mario Sanhueza, Eugene Kim, Maria de Haro, Francesco DeGiacomo, Cameron Torcassi, Jennifer Holcomb, Juliette Gafni, Sean D Mooney, Juan Botas, Lisa M Ellerby, Robert E Hughes   +14 more
doaj   +1 more source

Lessons Learned from the Transgenic Huntington's Disease Rats

Neural Plasticity, 2012
Huntington's disease (HD) is a fatal inherited disorder leading to selective neurodegeneration and neuropsychiatric symptoms. Currently, there is no treatment to slow down or to stop the disease.
Rinske Vlamings, Dagmar H. Zeef, Marcus L. F. Janssen, Mayke Oosterloo, Frederic Schaper, Ali Jahanshahi, Yasin Temel   +6 more
doaj   +1 more source

Resting-state fMRI reveals longitudinal alterations in brain network connectivity in the zQ175DN mouse model of Huntington's disease

Neurobiology of Disease, 2023
Huntington's disease is an autosomal, dominantly inherited neurodegenerative disease caused by an expansion of the CAG repeats in exon 1 of the huntingtin gene. Neuronal degeneration and dysfunction that precedes regional atrophy result in the impairment
Tamara Vasilkovska, Mohit H. Adhikari, Johan Van Audekerke, Somaie Salajeghe, Dorian Pustina, Roger Cachope, Haiying Tang, Longbin Liu, Ignacio Muñoz-Sanjuán, Annemie Van der Linden, Marleen Verhoye   +10 more
doaj  

Striatal disorders dissociate mechanisms of enhanced and impaired response selection — Evidence from cognitive neurophysiology and computational modelling

NeuroImage: Clinical, 2014
Paradoxically enhanced cognitive processes in neurological disorders provide vital clues to understanding neural function. However, what determines whether the neurological damage is impairing or enhancing is unclear.
Christian Beste, Mark Humphries, Carsten Saft   +2 more
doaj   +1 more source