Results 201 to 210 of about 93,886 (309)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Dysfunctions of sleep and the circadian rhythm in Huntington's disease. [PDF]

Front Neurol
Kaczmarska P, Rudzińska-Bar M.
europepmc   +1 more source

Psychosocial Impacts of Huntington's Disease on Individuals, Relatives and Family Systems: A Thematic Synthesis

Clinical Genetics, EarlyView.
The psychosocial impacts of Huntington's disease include disintegration with society, emotional and psychological burdens, an interplay of extrinsic stressors and recalibration of the family system. This thematic synthesis highlights the need for holistic, systemic support to address these pervasive challenges for all members of the affected family ...
Paige Lindo, Tierney Tindall, Suzanne Buswell, Selina Lock, Sarah Gunn   +4 more
wiley   +1 more source

Implant Therapy in Patients With Neurodegenerative Diseases—A Scoping Review

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives The increasing longevity of populations has resulted in a growing number of older adults requiring prosthodontic care, including those with neurodegenerative diseases (NDs). Neurodegenerative diseases pose significant challenges to prosthodontic care, and it remains unclear whether implant therapy in this population achieves ...
Lysandre David, Sabrina Maniewicz, Najla Chebib, Gabriel Gold, Murali Srinivasan, Frauke Müller   +5 more
wiley   +1 more source

Eye manifestations in Huntington's disease: an update on the potential of ocular biomarkers. [PDF]

J Neurol
Woods WA, Barker RA.
europepmc   +1 more source

18F-FDG PET/CT: an unexpected case of Huntington’s disease [PDF]

, 2019
Sebastian Michels, Hans‐Georg Buchholz, Florian Rosar, Isabel Heinrich, Manuela A. Hoffmann, Susann Schweiger, Oliver Tüscher, Mathias Schreckenberger   +7 more
openalex   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, EarlyView.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

Climate shocks, democratization and (a culture of) cooperation

Economica, EarlyView.
Abstract While the direct economic effects of adverse climate shocks are well known, their indirect institutional impact is still poorly understood. To clarify this, we test the idea that adverse climate shocks push time‐inconsistent elites to enact inclusive political institutions, and non‐elites to embrace strong norms of cooperation.
Giacomo Benati, Carmine Guerriero
wiley   +1 more source

Examining Balance and the Likelihood of Falls in Huntington's Disease. [PDF]

Clin Park Relat Disord
Youhanan N, Kaur J, Hall A, Bagga K, Patel S, Sidhu A, Alskaf R, Shaik Z, Gilbert PE, Goble DJ, Corey-Bloom J.   +10 more
europepmc   +1 more source