Results 271 to 280 of about 10,552,439 (323)

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Serum lipids and disease progression in Huntington's disease: A retrospective cohort study. [PDF]

Chin Med J (Engl)
Zhang S, Cheng Y, Zhang L, Ma Y, Fu J, Yang T, Xia J, Li C, Burgunder J, Shang H.   +9 more
europepmc   +1 more source

Transcriptomic Evidence of Mitochondrial Double‐Stranded RNA Accumulation in Brain Aging and Alzheimer's Disease

Aging Cell, Volume 25, Issue 7, July 2026.
Mt‐dsRNA signatures increase in the human brain after midlife in parallel with disrupted mitochondrial RNA homeostasis and are further elevated in Alzheimer's disease, where they correlate with cognitive decline and neuropathology. These findings suggest that age‐related mitochondrial RNA dyshomeostasis may drive chronic inflammation and contribute to ...
Rachel L. Doser, Thomas J. LaRocca
wiley   +1 more source

Dysregulation of miRNAs in Sicilian Patients with Huntington's Disease. [PDF]

Diagnostics (Basel)
Salemi M, Schillaci FA, Salluzzo MG, Marchese G, Ventola GM, Perrotta CS, Di Stefano V, Lanza G, Ferri R.   +8 more
europepmc   +1 more source

A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Aging Cell, Volume 25, Issue 7, July 2026.
Aging‐associated MLKL upregulation in hepatocytes induces mitochondrial dysfunction and oxidative stress, accompanied by increased release of pro‐inflammatory extracellular vesicles. These changes are associated with increased p16+/p21+ senescence in hepatocytes and non‐parenchymal cells (macrophages, stellate cells, and endothelial cells), suggesting ...
Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran, Phoebe Ohene‐Marfo, Kara F. Kneuper, Constantin Georgescu, Kamille Pitts, Albert Tran, Zongkai Peng, Amit Singh, Zhibo Yang, Tiangang Li, Bethany Hannafon, Courtney Houchen, Jonathan D. Wren, Andriy Yabluchanskiy, Veronica Galvan, Nagib Ahsan, Michael Kinter, Tommy L. Lewis Jr, Sathyaseelan S. Deepa   +21 more
wiley   +1 more source

Childhood-Onset Huntington's Disease-Like Presentation of SCA17 with Intermediate Repeats, A Case Report. [PDF]

Cerebellum
Berns M, Jensen K, Speltz L, Almeida LB.
europepmc   +1 more source

Karyopherin Dysfunction Is a Key Driver of Aging

Aging Cell, Volume 25, Issue 7, July 2026.
Studies on the proteostasis network and aging have focused on protein synthesis, folding, and turnover. Here, emphasis on the spatial dimension in proteostasis is proposed by recognizing nucleocytoplasmic transport as an important player in aging. ABSTRACT Aging is often framed as the gradual erosion of proteostasis, driven by declining chaperone ...
Louis R. Lapierre
wiley   +1 more source

Profiles of patients at early stages of Huntington's disease based on the routine biological markers and the disease progression. [PDF]

J Neurol
Gil-Salcedo A, Massart R, Youssov K, Morgado G, Bachoud-Levi AC.   +4 more
europepmc   +1 more source

Overview of Huntington's Disease and Emerging Treatment Strategies: A Narrative Review. [PDF]

Cureus
Vega AJ, Hernandez GV, O'Malley PA, Robin CJ, Parra AN, Varrassi G, Shekoohi S, Kaye AD.   +7 more
europepmc   +1 more source

Reduced Dopamine Transporter Uptake in Dentatorubral‐Pallidoluysian Atrophy

Movement Disorders Clinical Practice, Volume 13, Issue 7, Page 1769-1771, July 2026.
Kei Okuba, Shugo Fujita, Hitoshi Kawasaki, Genko Oyama   +3 more
wiley   +1 more source