Results 101 to 110 of about 9,184,817 (390)

Suicidality in Huntington's disease

Journal of Affective Disorders, 2012
In Huntington's disease (HD) the risk of suicide is increased. Since suicidality may precede suicide, this study investigates prevalence, clinical associations and predictors of suicidality in HD.Suicidality was investigated in 152 mutation carriers and 56 non-carriers, and was considered present if the score on the item 'suicidal ideation' of the ...
Hubers, A.A.M., Reedeker, N., Giltay, E.J., Roos, R.A.C., Duijn, E. van, Mast, R.C. van der   +5 more
openaire   +6 more sources

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, EarlyView.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

Alpha-Pinene Effect on Passive Avoidance Memory and CDK5 Gene Expression in the Rat Model of Huntington\'s Disease Induced by 3-Nitropropionic Acid [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان
Background and Aim: Huntington's disease is a chronic hereditary disorder that causes cognitive and movement defects in affected individuals by progressive destruction of neurons in the cerebral cortex, striatum and the hippocampus.
Paria Hashemi, Mohammad Raman Moloudi, Helia Rahmani, Zakaria Vahabzadeh, Esmael Izadpanah   +4 more
doaj  

Enfermedad de Huntington: estado del arte [PDF]

, 2014
La enfermedad de Huntington es un desorden monogenético autosómico dominante, que genera un trastorno neurodegenerativo caracterizado por la pérdida de neuronas en diferentes partes del cerebro.
Rodas Sepúlveda, Carlos Daniel, Sierra García, Natalia   +1 more
core  

The differential diagnosis of chorea [PDF]

, 2007
Chorea is a hyperkinetic movement disorder characterised by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. In this article, the authors discuss the causes of chorea, particularly Huntington's disease and the ...
Tabrizi, SJ, Wild, EJ
core   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

A Drosophila model of Huntington disease-like 2 exhibits nuclear toxicity and distinct pathogenic mechanisms from Huntington disease [PDF]

, 2016
Huntington disease-like 2 (HDL2) and Huntington disease (HD) are adult-onset neurodegenerative diseases characterized by movement disorders, psychiatric disturbances and cognitive decline.
Cho, Richard W., Krench, Megan A., Littleton, J. Troy   +2 more
core   +1 more source

MSH3 modifies somatic instability and disease severity in Huntington’s and myotonic dystrophy type 1

Brain : a journal of neurology, 2019
A genome-wide association study recently identified an MSH3/DHFR locus associated with Huntington’s disease progression. Flower, Lomeikaite et al. identify tandem repeat variants at this locus, and show that a three-repeat allele is associated with ...
M. Flower, Vilija Lomeikaite, Marc Ciosi, S. Cumming, F. Morales, K. Lo, Davina J. Hensman Moss, L. Jones, P. Holmans, D. Monckton, S. Tabrizi, P. Kraus, Rainer Hoffman, Alan Tobin, B. Borowsky, S. Keenan, K. Whitlock, S. Queller, Colin Campbell, Chiachi Wang, D. Langbehn, E. Axelson, H. Johnson, T. Acharya, D. Cash, C. Frost, Rebecca Jones, C. Jurgens, E. 't Hart, J. van der Grond, Marie-Noelle N Witjes- Ane, R. Roos, E. Dumas, S. V. D. van den Bogaard, C. Stopford, D. Craufurd, J. Callaghan, N. Arran, D. Rosas, S. Lee, W. Monaco, A. O'Regan, C. Milchman, E. Frajman, I. Labuschagne, J. Stout, M. Campbell, S. Andrews, N. Bechtel, R. Reilmann, S. Bohlen, C. Kennard, C. Berna, S. Hicks, A. Durr, C. Pourchot, É. Bardinet, K. Nigaud, Romain Valabré, `. gue, S. Lehéricy, C. Marelli, C. Jauffret, D. Justo, B. Leavitt, J. Decolongon, A. Sturrock, A. Coleman, R. D. Santos, A. Patel, C. Gibbard, D. Whitehead, E. Wild, G. Owen, H. Crawford, I. Malone, N. Lahiri, Nick C Fox, N. Hobbs, R. Scahill, R. Ordidge, T. Pepple, J. Read, M. Say, B. Landwehrmeyer, F. Daidj, G. Bassez, Baptiste Lignier, Florence Couppey, Stéphanie Delmas, J. Deux, K. Hankiewicz, C. Dogan, Lisa Minier, P. Chevalier, Amira Hamadouche, M. Catt, V. V. van Hees, Sharon D. Catt, A. Schwalber, Juliane Dittrich, M. Kierkegaard, S. Wenninger, B. Schoser, A. Schüller, K. Stahl, H. Künzel, Martin Wolff, Annamirl Jellinek, Cecilia Moreno, G. Gorman, H. Lochmüller, M. Trenell, S. van Laar, L. Wood, Sophie Cassidy, J. Newman, S. Charman, Renae Steffaneti, Louise A. Taylor, A. Brownrigg, Sharon Day, A. Atalaia, J. Raaphorst, K. Okkersen, B. V. van Engelen, S. Nikolaus, Yvonne Cornelissen, M. van Nimwegen, D. Maas, Ellen Klerks, Sacha Bouman, H. Knoop, L. Heskamp, A. Heerschap, R. Rahmadi, P. Groot, T. Heskes, K. Kapusta, J. Glennon, Shaghayegh Abghari, A. Aschrafi, G. Poelmans, S. Treweek, Fiona Hogarth, R. Littleford, P. Donnan, A. Hapca, M. Hannah, E. Mckenzie, P. Rauchhaus, S. Cumming, D. Monckton, B. Adam, C. Faber, I. Merkies   +155 more
semanticscholar   +1 more source

Mitochondria in Huntington's disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder associated with involuntary abnormal movements (chorea), cognitive deficits and psychiatric disturbances. The disease is caused by an abnormal expansion of a CAG repeat located in exon 1 of the gene encoding the huntingtin protein (Htt) that confers a toxic function to the
Maria Damiano, Laurie Galvan, Laurie Galvan, Nicole Déglon, Nicole Déglon, Emmanuel Brouillet, Emmanuel Brouillet   +6 more
openaire   +5 more sources

m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An, Yuhao Wu, Jingzhe Han, Pingping Fang, Yi Bu, Guang Ji, Jinliang Deng, Xueqin Song   +7 more
wiley   +1 more source