Results 111 to 120 of about 127,473 (295)

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Nose-to Brain Direct Delivery of Nanodrug Formulations in Treatment of Neurological Disorders: A Review Study

Journal of Mazandaran University of Medical Sciences, 2021
Global prevalence of neurological disorders such as Parkinson's disease, Alzheimer's disease, epilepsy, and multiple sclerosis is steadily increasing, but, there is still no effective delivery system to deliver therapeutic amounts of drug into the ...
Sara Assadpour, Mohammad Reza Shiran, Javad Akhtari   +2 more
doaj  

NMDA receptor gene variations as modifiers in Huntington disease: a replication study. [PDF]

, 2011
Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset (AO) in Huntington disease (HD) have already been described.
Arning, L, Craufurd, D, de Yebenes, JG, Dose, M, Epplen, JT, Landwehrmeyer, GB, REGISTRY Investigators of the European Huntington's Disease Netw, The, Roos, RA, Saft, C, Tabrizi, SJ, Wieczorek, S   +10 more
core  

The Spectrum of Abnormal Tongue Movements: Review of Phenomenology, Etiology, and Differential Diagnosis

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Classifying abnormal tongue movements is challenging due to their varied presentations and limited visibility compared to other body parts. Accurate identification of the phenomenology guides physical examination and can point to specific diagnoses.
Nathaniel Bendahan, Seyed‐Mohammad Fereshtehnejad, Christos Ganos, Emily Swinkin, Anthony E. Lang   +4 more
wiley   +1 more source

Clostridium sporogenes bacteremia in an immunocompetent patient

IDCases, 2019
Of the 200 Clostridium spp. known to exist, approximately 30 have been associated with human disease. Commonly found in soil, marine sediment and mammalian intestinal tracts, these gram-positive bacilli are known to cause infections ranging from ...
Waiel Abusnina, Mena Shehata, Emhemmid Karem, Zeynep Koc, Elie Khalil   +4 more
doaj   +1 more source

Defining Quality of Life: The Perspective of People Living with Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Little is known about how people with Parkinson's conceptualize “quality of life.” Objective To describe the meaning of “quality of life” from the perspective of people with Parkinson's. Methods Participants (N = 42) were asked “What does the term ‘quality of life’ mean to you?” Definitions were analyzed using inductive qualitative ...
Samantha Dorrance, Richa Patel, Glenn T. Stebbins, Jamie L. Adams, Allison M. Allen, Tara Hastings, Soania Mathur, Onanong Phokaewvarangkul, Gary Rafaloff, Rajasumi Rajalingam, Anette Schrag, Christine Sun, Jennifer Mammen, Connie Marras   +13 more
wiley   +1 more source

The achievement and prospect of deep brain stimulation for the treatment of movement disorders

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Deep brain stimulation (DBS) was first used in the treatment of essential tremor in 1987, and later used in the treatment of advanced Parkinson's disease (PD), drug⁃refractory dystonia, other types of tremor and Tourette's syndrome, which can reduce the ...
Chao⁃shi NIU, Chi XIONG
doaj  

Huntingtin as an Actin Organizer: Structural and Functional Insights

Cytoskeleton, EarlyView.
M. Capizzi, S. Humbert
wiley   +1 more source

Genetic and Pathological Testing Attitudes for Parkinson's Disease in At‐Risk Relatives

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is increasingly recognized as a neurodegenerative disorder with a broad clinical spectrum and diverse biomarkers enabling early detection. α‐synuclein seed amplification assays (SAA) and genetic testing now allow identification of PD pathology in asymptomatic individuals.
Tal Weil, Anat Mirelman, Roy N. Alcalay, Nurit Omer, Penina Ponger, Avner Thaler   +5 more
wiley   +1 more source