Results 121 to 130 of about 9,130,139 (414)
Alpha-Pinene Effect on Passive Avoidance Memory and CDK5 Gene Expression in the Rat Model of Huntington\'s Disease Induced by 3-Nitropropionic Acid [PDF]
مجله علمی دانشگاه علوم پزشکی کردستانBackground and Aim: Huntington's disease is a chronic hereditary disorder that causes cognitive and movement defects in affected individuals by progressive destruction of neurons in the cerebral cortex, striatum and the hippocampus.
Paria Hashemi +4 more
doaj
The differential diagnosis of chorea [PDF]
, 2007 Chorea is a hyperkinetic movement disorder characterised by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. In this article, the authors discuss the causes of chorea, particularly Huntington's disease and the ...
Tabrizi, SJ, Wild, EJ
core +1 more source
Pediatric Neurology Briefs, 1989 The positron-emission tomography (PET) findings in a seven year old girl with the juvenile form of Huntington's disease are described from the Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, Canada.
openaire +3 more sources
Blood DDIT4 and TRIM13 Transcript Levels Mark the Early Stages of Machado–Joseph Disease
Annals of Neurology, EarlyView.Objective An abundance of select transcripts and proteins has been found to be dysregulated in blood samples of Machado–Joseph disease (MJD) carriers. Here, we aimed to: (1) identify blood transcriptional changes as potential biomarkers of MJD; (2) correlate levels of differentially expressed blood transcripts with MJD carriers features; and (3 ...
Ana F. Ferreira +10 more
wiley +1 more source
Scientific ReportsSodium serves as one of the primary cations in the central nervous system, playing a crucial role in maintaining normal brain function. In this study, we investigated alterations in sodium concentrations in the brain and/or cerebrospinal fluid across ...
Chenchen Xia +11 more
doaj +1 more source
Meta-analysis of Gene Expression in Neurodegenerative Diseases Reveals Patterns in GABA Synthesis and Heat Stress Pathways [PDF]
arXiv, 2019 Neurodegenerative diseases are characterized as the progressive loss of neural cells, e.g. neurons, glial cells. Ageing, monogenic variations, viral infections, and many other factors are determined and speculated as causes for them. While many individual genes, such as APP for Alzheimer disease and HTT for Huntington disease, and biological pathways ...
arxiv
Disruption of the mitochondrial network in a mouse model of Huntington's disease visualized by in tissue multiscale 3D electron microscopy [PDF]
Acta neuropathol commun 12, 88 (2024)Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the coding sequence of the huntingtin protein. Initially, it predominantly affects medium-sized spiny neurons (MSSNs) of the corpus striatum. No effective treatment is available, thus urging the identification of potential therapeutic targets. While
arxiv +1 more source
Annals of Neurology, EarlyView.Artificial intelligence (AI) applications are finding use in real‐world neurological settings. Whereas part 1 of this 3‐part review series focused on the birth of AI and its foundational principles, this part 2 review shifts gears to explore more practical aspects of neurological care.
Matthew Rizzo
wiley +1 more source
CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease.
Brain : a journal of neurology, 2019 Dysfunctions in brain cholesterol homeostasis have been extensively related to brain disorders. The main pathway for brain cholesterol elimination is its hydroxylation into 24S-hydroxycholesterol by the cholesterol 24-hydrolase, CYP46A1.
Radhia Kacher +17 more
semanticscholar +1 more source
A Drosophila model of Huntington disease-like 2 exhibits nuclear toxicity and distinct pathogenic mechanisms from Huntington disease [PDF]
, 2016 Huntington disease-like 2 (HDL2) and Huntington disease (HD) are adult-onset neurodegenerative diseases characterized by movement disorders, psychiatric disturbances and cognitive decline.
Cho, Richard W. +2 more
core +1 more source