Results 151 to 160 of about 9,201,564 (391)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Nose-to Brain Direct Delivery of Nanodrug Formulations in Treatment of Neurological Disorders: A Review Study

Journal of Mazandaran University of Medical Sciences, 2021
Global prevalence of neurological disorders such as Parkinson's disease, Alzheimer's disease, epilepsy, and multiple sclerosis is steadily increasing, but, there is still no effective delivery system to deliver therapeutic amounts of drug into the ...
Sara Assadpour, Mohammad Reza Shiran, Javad Akhtari   +2 more
doaj  

A companion to the development of common data elements for Sudden Unexpected Death in Epilepsy (SUDEP)

Epilepsia Open, EarlyView.
Abstract Objective Sudden unexpected death in epilepsy (SUDEP) is a rare but devastating consequence of epilepsy and is the leading cause of death in people with epilepsy. SUDEP is associated with certain characteristics such as the presence of generalized tonic–clonic seizures, duration of epilepsy, and refractoriness to anti‐seizure medications ...
Sloka S. Iyengar, Elaine K. O'Loughlin, Lauren Harte‐Hargrove, Mary Holmay, Laura S. Lubbers, CURE Epilepsy SUDEP Data Standardization Project Steering Committee, Working Group Members, Lisa M. Bateman, Edward Glasscock, Samden Lhatoo, Philippe Ryvlin, Kristina Simeone, Charles Akos Szabo, Gardiner Lapham, David Auerbach, Gordon Buchanan, Jeffrey Buchhalter, Beate Diehl, Elizabeth Donner, Carl Faingold, Daniel Friedman, Christina Gross, Bin Gu, Franck Kalume, David Ryan King, Nuria Lecumberri, Susanne Mueller, William Nobis, Jeffrey Noebels, Terence O’Brien, Manoj Patel, George Richerson, Steven Schachter, Timothy Simeone, Ian Wenker   +34 more
wiley   +1 more source

A Recurrent Expansion of a Maternal Allele with 36 CAG Repeats Causes Huntington Disease in Two Sisters [PDF]

, 2000
Franco Laccone, Wilhelm Christian
openalex   +1 more source

Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain [PDF]

, 2001
Ellen Sapp, Kimberly B. Kegel, Neil Aronin, Tsutomu Hashikawa, Yasuo Uchiyama, Koujiro Tohyama, Pradeep G. Bhide, J.-P. G. Vonsattel, Marian DiFiglia   +8 more
openalex   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

Measurement of Mutational Flow Implies Both a High New-Mutation Rate for Huntington Disease and Substantial Underascertainment of Late-Onset Cases [PDF]

, 2001
Daniel Falush, E. Almqvist, Ryan R. Brinkmann, Yoh Iwasa, Michael R. Hayden   +4 more
openalex   +1 more source

Deciphering of nutritional profile, therapeutic potential, and networking of bioactive compounds of Moringa oleifera: A comprehensive review

Food Biomacromolecules, EarlyView.
The graphical abstract signifies the nutritional profile of various parts of the Moringa oleifera plant, including dried leaves, fresh leaves, leaf powder, seeds, and pods; along with it’s bioactive substance and protein profiling of aqueous concentrates derived from the fruit, seed, and leaf.
Rajesh Kumar, Sunita Khatak, Vandana, Adarsh Kumar Shukla, Surbhi Panwar, Ashwani Kumar   +5 more
wiley   +1 more source

Psychological impact of news of genetic risk for Huntington disease [PDF]

, 2001
Mardi J. Horowitz, Nigel P. Field, Andrea Zanko, Edward F. Donnelly, Charles J. Epstein, Frank M. Longo   +5 more
openalex   +1 more source

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source